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Merck
CN

C6617

CBIQ

≥98% (HPLC), solid

Synonym(s):

4-Chlorobenzo[f]isoquinoline

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About This Item

Empirical Formula (Hill Notation):
C13H8NCl
CAS Number:
32081-28-0
Molecular Weight:
213.66
NACRES:
NA.77
PubChem Substance ID:
24724450
UNSPSC Code:
12352200
MDL number:
MFCD02179769

Key Documents

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color

off-white

InChI key

SHQLTRRYZVBEMR-UHFFFAOYSA-N

SMILES string

Clc1nccc2c1ccc3ccccc23

InChI

1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H

assay

≥98% (HPLC)

form

solid

solubility

DMSO: 15 mg/mL

Quality Level

100

Biochem/physiol Actions

CBIQ is a cystic fibrosis transmembrane conductance regulator (CFTR) activator; intermediate-conductance calcium-sensitive K+ channel (KCNN4) activator.
CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

Features and Benefits

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
036K47071
036K4707

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Articles

Chloride Channels

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Potassium Channels

We offer many products related to potassium channels for your research needs.

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