C6617
CBIQ
≥98% (HPLC), solid
Synonym(s):
4-Chlorobenzo[f]isoquinoline
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About This Item
Empirical Formula (Hill Notation):
C13H8NCl
CAS Number:
Molecular Weight:
213.66
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality Segment
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
DMSO: 15 mg/mL
SMILES string
Clc1nccc2c1ccc3ccccc23
InChI
1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H
InChI key
SHQLTRRYZVBEMR-UHFFFAOYSA-N
Biochem/physiol Actions
CBIQ is a cystic fibrosis transmembrane conductance regulator (CFTR) activator; intermediate-conductance calcium-sensitive K+ channel (KCNN4) activator.
CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.
Features and Benefits
This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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