Name: Chondroitin sulfate sodium salt from bovine cartilage
Brand: SIGMA

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About This Item

CAS Number:

9082-07-9

UNSPSC Code:

12352201

PubChem Substance ID:

24892886

NACRES:

NA.25

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biological source

bovine cartilage

Quality Level

200

grade

standard (for CPC (cetylpyridinium chloride) titration)

Assay

98-102% (CPC, titration)

form

powder

optical activity

[α]20/D -30 to -20 °, c = 5% (w/v) in water

impurities

<10.0% water (Karl Fischer)

color

white to off-white

solubility

H₂O: soluble 50 mg/mL, clear to hazy, colorless to faintly yellow

cation traces

Na: 7.4-8.8% (anhydrous)

storage temp.

2-8°C

SMILES string

[Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]2O[C@@H]([C@H](O)[C@@H](O)[C@@H]2O)C(O)=O

InChI

1S/C14H23NO15S.Na/c1-3(17)15-5-10(9(30-31(24,25)26)4(2-16)27-13(5)23)28-14-8(20)6(18)7(19)11(29-14)12(21)22;/h4-11,13-14,16,18-20,23H,2H2,1H3,(H,15,17)(H,21,22)(H,24,25,26);/q;+1/p-1/t4-,5-,6-,7-,8+,9+,10-,11+,13-,14+;/m1./s1

InChI key

SHQAYVXGAAXVHV-GNAIRZFJSA-M

General description

Chondroitin, a glucosaminoglycan (GAG), is a polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA) that can be sulfated on the either or both GalNAc and GlcA units. Chondroitin and its sulfates are frequently attached to proteins to form proteoglycans.

Application

Chondroitin sulfate, a glucosaminoglycan (GAG) polysaccharide chain of alternating units of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcA), is used in a wide variety of areas of research including bioengineering. Chondroitin sulfate may be used as a biomaterial copolymer or surface derivatization reagent in the development of drug delivery vehicles, tissue engineering devices and bioscaffolds. Chondroitin sulfate may be used for the development of biocompatible structures such as hydrogels, sponges, biofilms, microspheres and micelles.

Biochem/physiol Actions

As a large, negatively charged, hydrophilic molecule that is too inflexible to fold into a compact globular structure, chondroitin sulfate molecules form porous hydrated gels, providing mechanical support to tissue and allowing rapid diffusion of water-soluble molecules and migration of cells.

Preparation Note

This product is soluble in water at 100 mg/mL.

Other Notes

Chondroitin is an acidic mucopolysaccharide found in cartilage, skin, cornea, and umbilical cord. It is composed of alternating N-acetylgalactosamine, D-glucuronic acid, and sulfate residues in equimolar quantities that can be sulfated on either of its subunits. Sulfation can occur at the 6 and/or 4-position of the galactosamine moiety, with potential for any individual disaccharide unit to be 6-sulfated, 4-sulfated, 4,6-disulfated, or unsulfated.

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Disclaimer

Store this product at 2-8°C.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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