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C7078

Sigma-Aldrich

Casein from bovine milk

technical grade

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CAS Number:
9000-71-9
EC Number:
232-555-1
MDL number:
MFCD00081481
NACRES:
NA.61

biological source

bovine milk

Quality Level

300

grade

technical grade

form

powder

technique(s)

activity assay: suitable
electrophoresis: suitable
immunocytochemistry: suitable

mp

280 °C (dec.) (lit.)

UniProt accession no.

P02662
P02663
P02666

InChI

1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)

InChI key

BECPQYXYKAMYBN-UHFFFAOYSA-N

Gene Information

bovine ... CSN1S1(282208) , CSN1S2(282209) , CSN2(281099)

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General description

Casein from bovine milk is a phosphoprotein. There are four main types of casein which make up approximately 80% of the total protein in bovine milk: α-s1 Casein, α-s2 Casein, β-Casein, and κ-Casein. Casein is proposed to be the main protective constituent in milk and is generally recognized as safe (GRAS) due to its naturally biocompatible and biodegradable properties.

Application

Casein from bovine milk has been used as:
  • a blocking agent in immunochemistry
  • a substrate to determine the casinolytic activity in disintegrin and Cerastes cerastes venom
  • as a fining agent to test its effect on white wine protein stabilization

Casein from bovine milk is a phosphoprotein. There are four main types of Casein which make up approximately 80% of the total protein in bovine milk: α-s1 Casein, α-s2 Casein, β-Casein, and κ-Casein. Casein is proposed to be the main protective constituent in milk

Biochem/physiol Actions

Casein finds application in nutraceuticals and various formulations such as hydrogels, films, nano micelles, and nanoparticles due to its properties such as emulsification, foaming, gelation, water-holding capacity, and interaction with bioactive molecules through functional groups. This protein is easily available, and it protects drugs from enzymatic degradation and nontoxicity so, casein is potentially used in oral delivery systems.
Partial gastrointestinal digestion of casein is a rich source of bioactive peptides, such as β-casomorphin. However, bovine casein is not homogeneous; variants A1 and B do lead to production of β-casomorphin 7 production, while A2 does not.

Other Notes

This product is technical grade casein. When compared to partially purified casein products, the technical grade has more protein impurities present and higher fat content.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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C Poelaert et al.
Animal : an international journal of animal bioscience, 12(6), 1154-1164 (2017-11-03)
Over the past decade, in vitro methods have been developed to study intestinal fermentation in pigs and its influence on the digestive physiology and health. In these methods, ingredients are fermented by a bacterial inoculum diluted in a mineral buffer
Junko Kasuya et al.
Journal of neurogenetics, 33(3), 164-178 (2019-05-18)
The Drosophila mutant paraShu harbors a dominant, gain-of-function allele of the voltage-gated sodium channel gene, paralytic (para). The mutant flies display severe seizure-like phenotypes, including neuronal hyperexcitability, spontaneous spasms, ether-induced leg shaking, and heat-induced convulsions. We unexpectedly found that two
Maj Linea Vestergaard et al.
Stem cells and development, 26(21), 1566-1577 (2017-08-11)
The derivation of functional cardiomyocytes (CMs) from human embryonic stem cells (hESCs) represents a unique way of studying human cardiogenesis, including the development of CM subtypes. In this study, we investigated the development and organization of hESC-derived cardiomyocytes (hESC-CMs) and
Baoguo Xu et al.
Ultrasonics sonochemistry, 63, 104930-104930 (2020-01-17)
Effect of multi-frequency power ultrasound (MFPU) pretreatments on the degree of hydrolysis (DH) and mechanism of casein during alcalase enzymolysis was investigated. Results showed that MFPU pretreatment in tri-frequency 20/40/60 kHz mode significantly (p < 0.05) improved the DH value of casein. Variation
Vabitha Shetty et al.
The Journal of clinical pediatric dentistry, 35(4), 389-392 (2011-11-04)
To estimate Calcium and Phosphorus withdrawal from hydroxyapatite in the presence of bovine milk and human milk from which the following protective fractions namely Casein, Whey protein, Lactose and Milk fat have been individually removed and to compare the above
View All Related Papers

Protocols

Enzymatic Assay of Ficin (EC 3.4.22.3)

This procedure may be used for all Ficin products.

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