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Merck
CN

C7518

L-Carnitine hydrochloride

≥97%, from equine muscle

Synonym(s):

(−)-β-Hydroxy-γ-(trimethylammonio)butyrate, Vitamin BT

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About This Item

Linear Formula:
(CH3)3N+CH2CH(OH)CH2CO2H · Cl-
CAS Number:
6645-46-1
Molecular Weight:
197.66
UNSPSC Code:
12352200
PubChem Substance ID:
24892966
EC Number:
229-663-6
MDL number:
MFCD00066100

Key Documents

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InChI key

JXXCENBLGFBQJM-FYZOBXCZSA-N

InChI

1S/C7H15NO3.ClH/c1-8(2,3)5-6(9)4-7(10)11;/h6,9H,4-5H2,1-3H3;1H/t6-;/m1./s1

SMILES string

[Cl-].C[N+](C)(C)C[C@H](O)CC(O)=O

biological source

equine muscle

assay

≥97%

storage temp.

−20°C

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Biochem/physiol Actions

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
110M5174V
110M5174
040M5159
089K5171
039K5163

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Johana Vásquez-Procopio et al.
Metallomics : integrated biometal science, 12(2), 218-240 (2019-12-05)
Manganese is considered essential for animal growth. Manganese ions serve as cofactors to three mitochondrial enzymes: superoxide dismutase (Sod2), arginase and glutamine synthase, and to glycosyltransferases residing in the Golgi. In Drosophila melanogaster, manganese has also been implicated in the
Aris A Polyzos et al.
Cell metabolism, 29(6), 1258-1273 (2019-04-02)
The basis for region-specific neuronal toxicity in Huntington disease is unknown. Here, we show that region-specific neuronal vulnerability is a substrate-driven response in astrocytes. Glucose is low in HdhQ(150/150) animals, and astrocytes in each brain region adapt by metabolically reprogramming
Silvana Constantinescu et al.
Canadian journal of physiology and pharmacology, 93(11), 913-922 (2015-09-26)
We have shown that reduced expression of receptor-interacting protein 140 (RIP140) alters the regulation of fatty-acid (FA) oxidation in muscle. To determine whether a high level of FA availability alters the effects of RIP140 on metabolic regulation, L6 myotubes were
Vladimir V Dynnik et al.
PloS one, 10(7), e0134145-e0134145 (2015-07-29)
The aim of present study was to investigate the effects of ammonium ions on in vitro neuronal network activity and to search alternative methods of acute ammonia neurotoxicity prevention. Rat hippocampal neuronal and astrocytes co-cultures in vitro, fluorescent microscopy and

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