C7522
Calcium Ionophore A23187
≥98% (TLC), ATPase inhibitor, powder
Synonym(s):
Calcimycin, Antibiotic A 23187, Calimycin
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About This Item
Empirical Formula (Hill Notation):
C29H37N3O6
CAS Number:
Molecular Weight:
523.62
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
258-084-1
MDL number:
Beilstein/REAXYS Number:
1096801
Product Name
Calcium Ionophore A23187, ≥98% (TLC), powder
sterility
non-sterile
Quality Level
assay
≥98% (TLC)
form
powder
color
white to light yellow
solubility
ethanol: 5 mg/mL, DMSO: 50 mg/mL
antibiotic activity spectrum
Gram-positive bacteria, fungi
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5
InChI
1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1
InChI key
HIYAVKIYRIFSCZ-CYEMHPAKSA-N
General description
Calcium ionophore A23187 is a carboxylic acid antibiotic with weak in vitro activity against Gram-positive organisms. It increases the potential of divalent ions to cross biological membranes, thus it acts as an ionophore. Calcium ionophore A23187 specifically forms stable 2:1 complex with divalent cations, rendering these ions soluble in ordinary organic solvents. Since calcium ionophore A23187 is commonly used to increase intracellular Ca2+ levels in intact cells, it acts as an uncoupler of oxidative phosphorylation and an inhibitor of mitochondrial adenosine triphosphatase (ATPase) activity. Calcium Ionophore A23187 is a potent inducer of phosphorylation of Toxoplasma eukaryotic initiation factor-2α (eIF2α). It also induces apoptosis in mouse lymphoma cell line (S49)7 but also has been shown to block apoptosis in other systems, such as when interleukin-3 (IL-3) is withdrawn from IL-3-dependent cells. Calcium ionophore A23187 is widely used as artificial activating substances for human oocytes.
with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.
with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.
Application
Calcium ionophore A23187 has been used:
- as an endoplasmic reticulum (ER) stress inducer to study its effect on the expression of the toxoplasma unfolded protein response (UPR) genes
- for the induction of the acrosome reaction
- in skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity assay
Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
涉药品监管产品
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Sharissa L Latham et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(2), 672-683 (2012-11-20)
Elevated endothelial microparticle (MP) levels are observed in numerous diseases, increasingly supporting roles as effectors and valuable markers of vascular dysfunction. While a contractile role for the actin cytoskeleton has been implicated in vesiculation, i.e., MP production, the precise interactions
Armen V Gyulkhandanyan et al.
British journal of haematology, 161(2), 245-254 (2013-02-13)
Anucleate platelets perform two fundamental processes, activation and apoptosis. We elaborated an approach for selective and concurrent stimulation of platelet apoptosis and/or activation, processes important in haemostasis and platelet clearance. Human platelets were treated with BH3 mimetic ABT-737, thrombin, calcium
Ian T Foe et al.
mSphere, 3(5) (2018-09-21)
Hydrolase are enzymes that regulate diverse biological processes, including posttranslational protein modifications. Recent work identified four active serine hydrolases (ASHs) in Toxoplasma gondii as candidate depalmitoylases. However, only TgPPT1 (ASH1) has been confirmed to remove palmitate from proteins. ASH4 (TgME49_264290)
Jeannine Winkler et al.
Thrombosis and haemostasis, 109(3), 532-539 (2013-01-12)
Although platelets possess the hallmarks of apoptosis such as activation of caspases, cytochrome c release and depolarisation of the mitochondrial transmembrane potential (∆Ψm), their entire apoptotic-signalling pathway is not totally understood. Therefore we studied the expression of various apoptotic proteins
Sebastian Lourido et al.
The EMBO journal, 31(24), 4524-4534 (2012-11-15)
Calcium signalling coordinates motility, cell invasion, and egress by apicomplexan parasites, yet the key mediators that transduce these signals remain largely unknown. One underlying assumption is that invasion into and egress from the host cell depend on highly similar systems
Related Content
Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C7522-10MG | 04061833512715 |
| C7522-50MG | 04061833512753 |
| C7522-1MG | 04061833512739 |
| C7522-5MG | 04061833512760 |
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