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C7527

Choline chloride

Name: Choline chloride
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98%

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Synonym(s):

(2-Hydroxyethyl)trimethylammonium chloride

Linear Formula:

(CH₃)₃N(Cl)CH₂CH₂OH

CAS Number:

67-48-1

Molecular Weight:

139.62

Beilstein:

3563126

EC Number:

200-655-4

MDL number:

MFCD00011721

PubChem Substance ID:

24892968

NACRES:

NA.75

biological source

synthetic (organic)

Quality Level

300

product line

BioReagent

Assay

≥98%

form

crystals

mol wt

M_w 139.62 g/mol

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable
cell culture | plant: suitable

color

white

pH

5.0-6.5 (25 °C, 140 g/L)

mp

302-305 °C (dec.) (lit.)

solubility

H₂O: 50 mg/mL

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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Related Categories

Plant Culture Media

Vitamins

General description

Choline chloride is a quaternary ammonium salt and associates with hydrogen bond donors (HBD). It is essential for the vital physiological functions and is used as a nutritional additive. Choline is a source of methyl groups for methyl-transfer reactions.

Application

Choline chloride has been used:

as a component of choline acetyltransferase (ChAT) buffer and for choline uptake in cultured human neuroblastoma (SK-N-SH) cells
for choline standard curve generation for quantifying phospholipase D (PLD) activity
as a component of slice solution for the dissection of entorhinal-hippocampal brain slices

Biochem/physiol Actions

The enzymatic activities of butyrylcholinesterase (BChE) and paraoxonase 1 (PON1), two serum enzymes synthesized by the liver and related with inflammation, were decreased in a sepsis animal model injected with LPS. Choline chloride administered intravenously at 20 mg/kg body weight prevents the LPS-mediated decreases in the activities of these two enzymes .

Substrates

Choline acetyltransferase substrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Apoptosis of bovine granulosa cells: Intracellular pathways and differentiation

Carou MC, et al.

Acta Histochemica, 119(5), 462-470 (2017)

Choline: an essential nutrient for public health

Zeisel SH and Da Costa KA

Nutr. Rev, 67(11), 615-623 (2009)

Reporter lines based on the gexp02 promoter enable early quantification of sexual conversion rates in the malaria parasite Plasmodium falciparum.

Harvie P Portugaliza et al.

Scientific reports, 9(1), 14595-14595 (2019-10-12)

Transmission of malaria parasites from humans to mosquito vectors requires that some asexual parasites differentiate into sexual forms termed gametocytes. The balance between proliferation in the same host and conversion into transmission forms can be altered by the conditions of

Determination of high-affinity choline uptake (HACU) and choline acetyltransferase (ChAT) activity in the same population of cultured cells

Ray B, et al.

Brain Research, 1297(11), 160-168 (2009)

Functional calcium imaging in developing cortical networks

Dawitz J, et al.

Journal of Visualized Experiments, 119(56), e3550-e3550 (2011)

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