C7805
Anti-Collagen Type III (COL3A1) Antibody
mouse monoclonal, FH-7A
Synonym(s):
Anti-Collagen III antibody
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About This Item
Conjugate:
unconjugated
Clone:
FH-7A, monoclonal
Application:
DB, ELISA (i), IHC (f), WB
Citations:
54
Product Name
Monoclonal Anti-Collagen, Type III antibody produced in mouse, clone FH-7A, ascites fluid
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
FH-7A, monoclonal
mol wt
antigen 70 kDa
contains
15 mM sodium azide
species reactivity
human, rat
technique(s)
dot blot: suitable, immunohistochemistry (frozen sections): 1-4,000 using frozen sections of human skin, indirect ELISA: suitable, western blot: suitable using a denatured-reduced preparation
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COL3A1(1281)
rat ... Col3a1(84032)
General description
Collagen is a fibrous protein present in the extracellular framework of all vertebrates. Collagen type III is a 300 kD molecule that belongs to fibrillar collagens family found mainly in skin, blood vessels, liver, placenta, tongue and thymus. This collagen is directly or indirectly involved in several genetic diseases like Ehlers-Danlos type IV disease. Monoclonal anti-collagen type III antibody can be used to determine the interstitial collagen I and III content in total protein homogenates. It is also used to study the immunolocalization of collagen type III in normal and neoplastic tissue. Mouse monoclonal anti-collagen type III antibody reacts specifically with native and denatured collagen type III but not with collagen types I, II, IV, V, VI, and X.
Monoclonal Anti-Collagen Type III (mouse IgG1 isotype) is derived from the FH-7A hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human collagen type III.
Immunogen
human collagen type III
Application
Monoclonal Anti-Collagen, Type III antibody produced in mouse has also been used in enzyme linked immunosorbent assay (ELISA) and immunohistochemistry.
Monoclonal anti-collagen type III antibody has been used in immunofluorescence and western blot.
Biochem/physiol Actions
Monoclonal Anti-Collagen Type III reacts specifically with native and denatured collagen type III. It does not recognize collagen types I, II, IV, V, VI, and X.
This collagen is directly or indirectly involved in several genetic diseases like Ehlers-Danlos type IV disease. Monoclonal anti-collagen type III antibody can be used to determine the interstitial collagen I and III content in total protein homogenates.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
动物来源生物产品
常规特殊物品
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Related Content
Datasheet
R Mayne
Clinical biochemistry, 21(2), 111-115 (1988-04-01)
Monoclonal antibodies have recently been developed against all of the major collagen types isolated from both human and other species. These antibodies have several potential advantages over polyclonal antibodies, and a brief survey will be made of the different antibodies
Fluorescently labeled collagen binding proteins allow specific visualization of collagen in tissues and live cell culture
Krahn KN, et al.
Analytical Biochemistry, 350(2), 177-185 (2006)
Corinne N Riggin et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 37(9), 2035-2042 (2019-05-02)
Overuse-induced tendinopathy is highly prevalent in the general population. Percutaneous fenestration, or dry needling, techniques have been increasing in popularity, but despite their current use, there are no controlled laboratory studies to provide fundamental support for this practice. The objective
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C7805-.2ML | 04061837883538 |
| C7805-100UL | 04061837883545 |