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C7874

Piperaquine tetraphosphate tetrahydrate

Name: Piperaquine tetraphosphate tetrahydrate
Brand: SIGMA

≥98% (HPLC), autophagy inhibitor, powder

Synonym(s):

7-Chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₃₂Cl₂N₆·4H₃PO₄·4H₂O

CAS Number:

915967-82-7

Molecular Weight:

999.55

UNSPSC Code:

12352200

PubChem Substance ID:

329775155

NACRES:

NA.77

MDL number:

MFCD11870901

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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Product Name

Piperaquine tetraphosphate tetrahydrate, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

H₂O: ≥10 mg/mL

storage temp.

room temp

SMILES string

O.O.O.O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.OP(O)(O)=O.Clc1ccc2c(ccnc2c1)N3CCN(CCCN4CCN(CC4)c5ccnc6cc(Cl)ccc56)CC3

InChI

1S/C29H32Cl2N6.4H3O4P.4H2O/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29;4*1-5(2,3)4;;;;/h2-9,20-21H,1,10-19H2;4*(H3,1,2,3,4);4*1H2

InChI key

AMCQDGFOKTXHSY-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

Phosphates

Application

Piperaquine tetraphosphate tetrahydrate has been used to study its effect on the tert-butylhydroperoxide (t-BHP)-induced alterations of cell morphology and viability

Biochem/physiol Actions

Piperaquine tetraphosphate tetrahydrate is an antimalarial agent highly active against chloroquine-resistant Plasmodium falciparum and Plasmodium vivax.

Piperaquine tetraphosphate tetrahydrate is an autophagy inhibitor.

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000528548

0000420959

0000420965

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Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells.

Chuanhong Wu et al.

Scientific reports, 8(1), 574-574 (2018-01-14)

Neurodegenerative diseases (NDD) are typically associated with neuron loss in nervous system areas. Interventions with related death mechanisms may ameliorate NDD progression. Oxidative stress plays an important role in NDD cell death routines. However, tert-butylhydroperoxide (t-BHP), a widely used oxidative

Induction of ferroptosis and mitochondrial dysfunction by oxidative stress in PC12 cells.

Chuanhong Wu et al.

Scientific reports, 8(1), 574-574 (2018-01-14)

Antimalarial drugs and their metabolites are potent Zika virus inhibitors.

Yingshan Han et al.

Journal of medical virology, 91(7), 1182-1190 (2019-02-26)

Studies aimed at repurposing existing drugs revealed that some antimalarial compounds possess anti-Zika virus (anti-ZIKV) activity. Here, we further tested 14 additional antimalarial drugs and their metabolites or analogs for anti-ZIKV activity using a phenotypic screening approach. We identified four

Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Global Trade Item Number

SKU	GTIN
C7874-25MG	04061833521250
C7874-5MG	04061833521267

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