C7930
Anti-CD3, T Cell antibody produced in rabbit
whole antiserum
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB
Citations:
45
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
mol wt
antigen 20 kDa (bovine and swine)
contains
15 mM sodium azide
species reactivity
rat, canine, mouse, human, Psammomys (sand rat), sheep, feline, pig, chicken, bovine
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using enzyme pre-digested, formalin-fixed, paraffin-embedded human tonsil sections, western blot: 1:200 using mouse thymus extract
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CD3E(916)
mouse ... Cd3e(12501)
rat ... Cd3e(315609)
General description
CD3 is a 20kDa glycoprotein expressed on surface of all human T lymphocytes. CD3 molecule is encoded by the gene mapped to human chromosome 11q23.3. The CD3 antigen is expressed during thymopoiesis. It is also present in the majority of T-CLL and T-lymphomas and in approximately 70% of T-ALL.
Immunogen
synthetic human CD3 peptide (residues 156-168 of the CD3-ε chain) coupled to porcine thyroglobulin. Coupling was performed by a modification of the reported method.
Application
Anti-CD3, T Cell antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence staining
- immunohistochemistry
- immunohistochemical analysis
Biochem/physiol Actions
CD3 is a human cell surface glycoprotein complex involved in signal transduction following binding of antigen receptor.
The antibody reacts with the proline-rich peptide sequence comprising 13 amino acids in the cytoplasmic domain of the CD3-ε chain. It detects normal, reactive and most neoplastic human T cells in routinely processed enzyme pre-digested, formalin-fixed, paraffin-embedded tissue sections. The antibody also reacts with human tissues fixed with Bouin′s solution and embedded in paraffin. Frozen sections and smears are also suitable for staining with this antibody. The antibody reacts with T cell areas in lymphoid tissues derived from various species.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
nwg
Regulatory Information
动物来源生物产品
常规特殊物品
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Nadir Kadri et al.
Journal of immunology (Baltimore, Md. : 1950), 188(7), 3138-3149 (2012-03-01)
Type 1 diabetes (T1D) is a chronic autoimmune disease that results from T cell-mediated destruction of pancreatic β cells. CD1d-restricted NKT lymphocytes have the ability to regulate immunity, including autoimmunity. We previously demonstrated that CD1d-restricted type II NKT cells, which
Most Jacobsen syndrome deletion breakpoints occur distal to FRA11B.
Michaelis RC, et al.
American Journal of Medical Genetics (1998)
Fabian P S Yu et al.
Scientific reports, 8(1), 1808-1808 (2018-01-31)
Farber Disease (FD) is an ultra-rare Lysosomal Storage Disorder caused by deficient acid ceramidase (ACDase) activity. Patients with ACDase deficiency manifest a spectrum of symptoms including formation of nodules, painful joints, and a hoarse voice. Classic FD patients will develop
Chuanhai Cao et al.
Neurobiology of disease, 34(1), 63-70 (2009-01-27)
We have found that a small number of purified Th2-biased Abeta-specific T cells are sufficient to provide profound cognitive and pathological benefits in an APP+PS1 mouse model for Alzheimer's disease. Six weeks after receiving T cell infusions, cognitively-impaired mice performed
Effect of hormonal contraception on the function of plasmacytoid dendritic cells and distribution of immune cell populations in the female reproductive tract
Michel KG, et al.
Journal of Acquired Immune Deficiency Syndromes, 68(5), 511-511 (2015)
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C7930-.2ML | 04061833521373 |
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