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C8145

Cefsulodin sodium salt hydrate

Name: Cefsulodin sodium salt hydrate
Brand: SIGMA

third-generation cephalosporin antibiotic

Synonym(s):

7-(D-α-Sulfophenylacetamido)ceph-3-em-3-(4′-carbamoylpyridinium)methyl-4-carboxylate sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₁₉N₄NaO₈S₂ · xH₂O

CAS Number:

52152-93-9

Molecular Weight:

554.53 (anhydrous basis)

NACRES:

NA.85

PubChem Substance ID:

24278340

UNSPSC Code:

51284140

EC Number:

257-692-4

MDL number:

MFCD07793338

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Quality Level

200

form

powder or crystals

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

[Na+].NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S([O-])(=O)=O)C3=O)C([O-])=O)cc1

InChI

1S/C22H20N4O8S2.Na/c23-18(27)13-6-8-25(9-7-13)10-14-11-35-21-15(20(29)26(21)16(14)22(30)31)24-19(28)17(36(32,33)34)12-4-2-1-3-5-12;/h1-9,15,17,21H,10-11H2,(H4-,23,24,27,28,30,31,32,33,34);/q;+1/p-1/t15-,17-,21-;/m1./s1

InChI key

REACMANCWHKJSM-DWBVFMGKSA-M

Related Categories

Antibiotics

Biochemicals

Cell Culture Supplements & Reagents

Chemistry & Biochemicals

General description

Chemical structure: β-lactam

Application

Cefsulodin is a third generation cephalosporin antibiotic that has very specific activity against Pseudomonas aeruginosa. Cefuslodin is used in CIN (cefsulodin-Irgasan-novobiocin) agar to select for microorganisms such as E. coli. Cefsulodin is a substrate for rat Oatp1a4. It has been used to study multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across the mouse blood-brain barrier.

Cefsulodin is used to study the effect of expression, binding, and inhibition of PBP1 and other penicillin-binding proteins (PBPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefsulodin is a cephalosporin. Cephalosporins disrupt cell wall synthesis by inhibiting PBP crosslinking of peptidoglycan.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

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On-line microdialysis coupled with microbore liquid chromatography with ultraviolet detection for continuous monitoring of free cefsulodin in rat blood.

T H Tsai et al.

Journal of chromatography. A, 914(1-2), 83-87 (2001-05-19)

A microdialysis method followed by a microbore liquid chromatographic ultraviolet detection procedure has been performed for the assay of unbound cefsulodin in rat blood. A microdialysis probe was inserted into the jugular vein for blood sampling. This method involves an

Unstable Escherichia coli L forms revisited: growth requires peptidoglycan synthesis.

Danièle Joseleau-Petit et al.

Journal of bacteriology, 189(18), 6512-6520 (2007-06-26)

Growing bacterial L forms are reputed to lack peptidoglycan, although cell division is normally inseparable from septal peptidoglycan synthesis. To explore which cell division functions L forms use, we established a protocol for quantitatively converting a culture of a wild-type

The detection of Shiga toxin-producing Escherichia coli in diagnostic bovine faecal samples using vancomycin-cefixime-cefsulodin blood agar and PCR.

M A Hornitzky et al.

FEMS microbiology letters, 198(1), 17-22 (2001-04-28)

The prevalence of complex Shiga toxin-producing Escherichia coli (STEC), i.e. STEC containing accessory virulence factors intimin (eaeA) and/or enterohaemorrhagic E. coli haemolysin (ehxA) and their serotypes were determined in diagnostic bovine faecal samples processed during a 3 months period. The

Genotypic analyses of shiga toxin-producing Escherichia coli O157 and non-O157 recovered from feces of domestic animals on rural farms in Mexico.

Bianca A Amézquita-López et al.

PloS one, 7(12), e51565-e51565 (2012-12-20)

Shiga toxin-producing Escherichia coli (STEC) are zoonotic enteric pathogens associated with human gastroenteritis worldwide. Cattle and small ruminants are important animal reservoirs of STEC. The present study investigated animal reservoirs for STEC in small rural farms in the Culiacan Valley

Radiation induced effects on cephalosporins: an ESR study.

J P Basly et al.

International journal of radiation biology, 75(2), 259-263 (1999-03-11)

This paper reports experimental data on the ESR identification of four irradiated cephalosporins (cefpodoxime, cefsulodin, cefixime and ceftizoxime). Equations to describe the ESR curves versus the dose and storage time were developed using mathematical procedures. Limits of detection (LOD) and

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Global Trade Item Number

SKU	GTIN
C8145-250MG	04061833521861
C8145-1G	04061833521854
C8145-100MG	04061838820433

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