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Merck
CN

C8734

Z-Leu-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone

solid

Synonym(s):

Z-LETD-FMK

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About This Item

Empirical Formula (Hill Notation):
C30H44N4O11F
Molecular Weight:
655.69
UNSPSC Code:
12352200
PubChem Substance ID:
329775185
MDL number:
MFCD03452906

Key Documents

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Product Name

Z-Leu-Glu(OMe)-Thr-Asp(OMe)-fluoromethyl ketone, solid

InChI

1S/C30H43FN4O11/c1-17(2)13-22(34-30(43)46-16-19-9-7-6-8-10-19)28(41)32-20(11-12-24(38)44-4)27(40)35-26(18(3)36)29(42)33-21(23(37)15-31)14-25(39)45-5/h6-10,17-18,20-22,26,36H,11-16H2,1-5H3,(H,32,41)(H,33,42)(H,34,43)(H,35,40)/t18-,20+,21+,22+,26+/m1/s1

SMILES string

COC(=O)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(=O)OC)C(=O)CF

InChI key

ARECPHKVCIQJRJ-XGRWUTGMSA-N

assay

≥90% (TLC)

form

solid

storage temp.

−20°C

Application

Cell permeable caspase-8 inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
048K1091
105K1498
103K1520
071K1312
033K0765

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Xiao-Fan Huang et al.
Molecules (Basel, Switzerland), 25(23) (2020-12-04)
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Rajeev Kumar et al.
Toxicology and applied pharmacology, 283(3), 187-197 (2015-02-07)
Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3-phenyl-2H-1-benzopyran (BP), a SERM designed

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