C8742
CHIC-35
≥97% (chiral, HPLC)
Synonym(s):
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35
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About This Item
Empirical Formula (Hill Notation):
C14H15ClN2O
CAS Number:
Molecular Weight:
262.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (chiral, HPLC)
Form:
solid
assay
≥97% (chiral, HPLC)
form
solid
solubility
DMSO: >10 mg/mL, H2O: <2 mg/mL
storage temp.
2-8°C
SMILES string
ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1
InChI
1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
InChI key
ABIVOOWWGYJNLV-JTQLQIEISA-N
Biochem/physiol Actions
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1.
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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