C8849
α-Chloralose−HBC complex
≥92% α-anomer basis
Synonym(s):
1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose: 2-hydroxypropyl-β-cyclodextrin complex
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352200
assay
≥92% α-anomer basis
form
powder
shelf life
4 weeks at 4 °C (for aqueous solutions)
solubility
H2O: freely soluble
Quality Level
Application
α-Chloralose-HBC complex has been used for anesthetizing rats for various in vivo studies.
Biochem/physiol Actions
α-Chloralose-HBC complex is a preferred anesthetic over isoflurane as it displays no intrusion retinal spreading depolarization (rSD) generation and propagation.
Preparation Note
α-Chloralose content: 10% (w/w)
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type N95 (US)
Regulatory Information
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Tess E Kornfield et al.
eNeuro, 2(2) (2015-06-18)
Blood flow is a useful indicator of the metabolic state of the retina. However, accurate measurement of retinal blood flow is difficult to achieve in practice. Most existing optical techniques used for measuring blood flow require complex assumptions and calculations.
Anja I Srienc et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 36(9), 1579-1591 (2016-07-09)
Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known
Kyle R Biesecker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(36), 9435-9445 (2016-09-09)
The brain is critically dependent on the regulation of blood flow to nourish active neurons. One widely held hypothesis of blood flow regulation holds that active neurons stimulate Ca(2+) increases in glial cells, triggering glial release of vasodilating agents. This
J Silverman et al.
Laboratory animal science, 43(3), 210-216 (1993-06-01)
Chloral hydrate (CH) and alpha-chloralose (CS) are often used to anesthetize laboratory animals although, to our knowledge, there have been no controlled studies of their anesthetic or analgesic effects. Induction of and recovery from anesthesia can be stressful, and anesthesia
Tess E Kornfield et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(34), 11504-11513 (2014-08-22)
Light stimulation evokes neuronal activity in the retina, resulting in the dilation of retinal blood vessels and increased blood flow. This response, named functional hyperemia, brings oxygen and nutrients to active neurons. However, it remains unclear which vessels mediate functional
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