Key Documents

View All Documentation

C8895

Clofazimine

Name: Clofazimine
Brand: SIGMA

≥98% (TLC), powder, antimycobacterial rimonphenazine

Synonym(s):

N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₂Cl₂N₄

CAS Number:

2030-63-9

Molecular Weight:

473.40

NACRES:

NA.77

PubChem Substance ID:

24893114

UNSPSC Code:

12352200

EC Number:

217-980-2

MDL number:

MFCD00056793

Form:

powder

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Clofazimine,

form

powder

Quality Segment

200

antibiotic activity spectrum

mycobacteria

mode of action

protein synthesis | interferes

originator

Novartis

SMILES string

CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5

InChI

1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+

InChI key

WDQPAMHFFCXSNU-BGABXYSRSA-N

Description

General description

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Application

Clofazimine has been used:

for antimicrobial preparation
to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
to model drug-induced hepatic granulomatous inflammation
to study the in vivo cargo storage capacity of macrophages

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

This product is stored at room temperature.

Still not finding the right product?

Explore all of our products under Clofazimine

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000539225

0000539224