C9033
β-Chloro-L -alanine hydrochloride
Alanine aminotransferase inhibitor
Synonym(s):
(R)-2-Amino-3-chloropropanoic acid, 3-Chloro-L-alanine
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About This Item
Empirical Formula (Hill Notation):
C3H6ClNO2 · HCl
CAS Number:
Molecular Weight:
160.00
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
biological source
synthetic
Quality Segment
assay
≥98% (TLC)
form
powder
mp
205 °C
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl[H].N[C@@H](CCl)C(O)=O
InChI
1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
InChI key
IENJPSDBNBGIEL-DKWTVANSSA-N
Application
β-Chloro-L -alanine hydrochloride has been used:
- as a substrate for screening tyrosine phenol lyase steady state kinetics
- in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells
- as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system
Biochem/physiol Actions
β-Chloro-L -alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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