Key Documents

View All Documentation

C9124

CK-869

Name: CK-869
Brand: SIGMA

≥98% (HPLC), actin assembly inhibitor, powder

Synonym(s):

2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone, CK 869, CK-0157869

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₆BrNO₃S

CAS Number:

388592-44-7

Molecular Weight:

394.28

MDL number:

MFCD01844129

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

CK-869, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to light gray

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br

InChI

1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3

InChI key

MVWNPZYLNLATCH-UHFFFAOYSA-N

Description

Application

CK-869 has been used as an Arp2/3 complex inhibitor:

to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
to induce membrane blebbing in HT1080 fibrosarcoma cells
to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis

Biochem/physiol Actions

CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast.

CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library