C9124
CK-869
≥98% (HPLC), actin assembly inhibitor, powder
Synonym(s):
2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone, CK 869, CK-0157869
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About This Item
Empirical Formula (Hill Notation):
C17H16BrNO3S
CAS Number:
Molecular Weight:
394.28
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Product Name
CK-869, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to light gray
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br
InChI
1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
InChI key
MVWNPZYLNLATCH-UHFFFAOYSA-N
Application
CK-869 has been used as an Arp2/3 complex inhibitor:
- to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly
- to induce membrane blebbing in HT1080 fibrosarcoma cells
- to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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