C9367
Anti-CUGBP2 antibody, Mouse monoclonal
clone HL1889 (1H2-1F12), purified from hybridoma cell culture
Synonym(s):
Anti-CUG Triplet Repeat, RNA-binding protein 2, Anti-ETR3, RNA-binding protein
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About This Item
Conjugate:
unconjugated
Clone:
HL1889 (1H2-1F12), monoclonal
Application:
ICC, IP, WB
Citations:
6
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HL1889 (1H2-1F12), monoclonal
form
buffered aqueous solution
mol wt
antigen ~52 kDa
species reactivity
mouse, human, chicken
concentration
~1.5 mg/mL
technique(s)
immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: 30-40 μg/mL using total cell extract of mouse heart
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
chicken ... CUGBP2(374111)
human ... CUGBP2(10659)
mouse ... Cugbp2(14007)
General description
CUGBP2 is an RNA-binding protein that specificallybinds to CUG repeat sequences.
Immunogen
divergent domain of human CUGBP2 corresponding to amino acids 209-415 (accession no. NP006552).
Application
Suitable for immunocytochemistry, immunoprecipitation and western blotting at a working concentration of 30-40 μg/mL using total cell extract of mouse heart.
Biochem/physiol Actions
CUGBP2 is an RNA-binding protein that specifically binds to CUG repeat sequences and is responsible for the regulation of both nuclear and cytoplasmic RNA processing events such as alternative splicing, RNA editing, mRNA stability, and translation. It is mainly expressed in muscle and brain. It regulates a specific alternative slicing of exons 5 and 21 of the N-methyl-D-aspartate receptor 1 (NMDA R1) RNA in rat. It binds to U/G-rich motifs within muscle specific enhancer elements (MSEs) and activates inclusion of an alternative exon in cardiac troponin T (cTNT) pre-mRNAs. It interacts with A/U rich sequences in the 3′ UTR and inhibits translation of cycloxygenase-2 (COX-2) mRNAs.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Regulatory Information
低风险生物材料
常规特殊物品
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Astrid-Solveig Schultz et al.
Molecular and cellular biology, 37(7) (2016-12-30)
Cell-type-specific and inducible alternative splicing has a fundamental impact on regulating gene expression and cellular function in a variety of settings, including activation and differentiation. We have recently shown that activation-induced skipping of TRAF3 exon 8 activates noncanonical NF-κB signaling
Andrea N Ladd et al.
Journal of cell science, 117(Pt 16), 3519-3529 (2004-07-01)
Embryonic lethal abnormal vision (ELAV) type RNA binding protein 3 (ETR-3; also called NAPOR, CUGBP2, or BRUNOL3) has been implicated in the regulation of nuclear and cytoplasmic RNA processing events, including alternative splicing, RNA editing, stability and translation. Here, we
Andrea N Ladd et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 233(3), 783-793 (2005-04-15)
Cardiac troponin T (cTNT) exon 5 splicing is developmentally regulated such that it is included in embryonic but not adult heart. CUG-BP and ETR-3-like factor (CELF) proteins promote exon inclusion, whereas polypyrimidine tract binding protein (PTB) and muscleblind-like (MBNL) proteins
Wenqing Zhang et al.
RNA (New York, N.Y.), 8(5), 671-685 (2002-05-23)
Alternative RNA splicing generates extensive proteomic diversity in the nervous system, yet few neural-specific RNA binding proteins have been implicated in splicing control. Here we show that the biochemical properties and spatial expression of mouse neuroblastoma apoptosis-related RNA-binding protein (NAPOR;
Debnath Mukhopadhyay et al.
Molecular cell, 11(1), 113-126 (2003-01-22)
Cyclooxygenase-2 (COX-2) expression is translationally silenced in epithelial cells undergoing radiation-induced apoptosis. CUGBP2, a predominantly nuclear protein, is also rapidly induced in response to radiation and translocates to the cytoplasm. Antisense-mediated suppression of CUGBP2 renders radioprotection through a COX-2-dependent prostaglandin
Related Content
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C9367-200UL | 04061838025470 |
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