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C9625

L-Carnosine

~99%

Synonym(s):

β-Alanyl-L-histidine

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About This Item

Empirical Formula (Hill Notation):
C9H14N4O3
CAS Number:
305-84-0
Molecular Weight:
226.23
NACRES:
NA.26
PubChem Substance ID:
24893178
UNSPSC Code:
12352209
EC Number:
206-169-9
MDL number:
MFCD00005207
Beilstein/REAXYS Number:
87671
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Product Name

L-Carnosine, ~99%, crystalline

assay

~99%

Quality Segment

200

form

crystalline

color

white to off-white

mp

253 °C (dec.) (lit.)

application(s)

cell analysis

storage temp.

−20°C

SMILES string

NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C9H14N4O3/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6/h4-5,7H,1-3,10H2,(H,11,12)(H,13,14)(H,15,16)/t7-/m0/s1

InChI key

CQOVPNPJLQNMDC-ZETCQYMHSA-N

Gene Information

human ... CA1(759), CA2(760)

Application

L-Carnosine has been used to study its effects as an antioxidant on meat quality of pigs. It has also been used to study its effects on brain injury in a rat intracerebral hemorrhage model.

Biochem/physiol Actions

L-Carosine is a dipeptide found at millimolar concentration in brain, muscle and the lens of the eye. In model systems it is a potent antioxidant that scavenges oxygen free radicals and transition metal ions. It blocks protein-protein and protein-DNA cross-links induced by hypochlorite anions and toxic aldehydes such as acetaldehyde, formaldehyde, and malondialdehyde, the primary product of lipid peroxidation. It also inhibits nonenzymatic protein glycation induced by aldose and ketose reducing sugars and inhibits the formation of toxic advanced glycation end products (AGE). These activities make it of interest in studies of aging, atherosclerosis, Alzheimer′s disease, and the secondary effects of diabetes.
Dipeptide with potent antioxidant and antiglycation activity; blocks nonenzymatic glycosylation and protein cross-linking induced by reactive aldehydes.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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