C9749
CBiPES hydrochloride
≥98% (HPLC)
Synonym(s):
N-(4′-cyano[1,1′-biphenyl]-3-yl)-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C21H19N3O2S · HCl
CAS Number:
Molecular Weight:
413.92
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
off-white to light brown
solubility
DMSO: >20 mg/mL
originator
Eli Lilly
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(N(Cc3cnccc3)c1cc(ccc1)c2ccc(cc2)C#N)CC.Cl
InChI
1S/C21H19N3O2S.ClH/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19;/h3-13,15H,2,16H2,1H3;1H
InChI key
QKUHSVQWWZBAKM-UHFFFAOYSA-N
Biochem/physiol Actions
CBiPES is a positive allosteric modulator of the mGlu2 receptor.
CBiPES is a positive allosteric modulator of the mGlu2 receptor. CBiPES attenuates stress-induced hyperthermia and blocks the hyperlocomotor effects of PCP in murine models. In rat brain, CBiPES attenuates ketamine-induced increase in extracellular histamine concentration. This compound is a sulfonamide, different chemical class from other mGlu2R agonists in the Sigma catalog.
Features and Benefits
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Articles
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| C9749-5MG | 04061832270173 |
| C9749-25MG | 04061832270166 |