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Merck
CN

C9749

CBiPES hydrochloride

≥98% (HPLC)

Synonym(s):

N-(4′-cyano[1,1′-biphenyl]-3-yl)-N-(3-pyridinylmethyl)-ethanesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C21H19N3O2S · HCl
CAS Number:
856702-40-4
Molecular Weight:
413.92
MDL number:
MFCD18086913
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

CBiPES hydrochloride, ≥98% (HPLC)

SMILES string

[S](=O)(=O)(N(Cc3cnccc3)c1cc(ccc1)c2ccc(cc2)C#N)CC.Cl

InChI

1S/C21H19N3O2S.ClH/c1-2-27(25,26)24(16-18-5-4-12-23-15-18)21-7-3-6-20(13-21)19-10-8-17(14-22)9-11-19;/h3-13,15H,2,16H2,1H3;1H

InChI key

QKUHSVQWWZBAKM-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

off-white to light brown

solubility

DMSO: >20 mg/mL

originator

Eli Lilly

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

CBiPES is a positive allosteric modulator of the mGlu2 receptor.
CBiPES is a positive allosteric modulator of the mGlu2 receptor. CBiPES attenuates stress-induced hyperthermia and blocks the hyperlocomotor effects of PCP in murine models. In rat brain, CBiPES attenuates ketamine-induced increase in extracellular histamine concentration. This compound is a sulfonamide, different chemical class from other mGlu2R agonists in the Sigma catalog.

Features and Benefits

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000157693
011M4618V

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Articles

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