Key Documents

View All Documentation

C9873

CPTH2

Name: CPTH2
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

Cyclopentylidene-[4-(4-chlorophenyl)thiazol-2-yl)hydrazone

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₄H₁₄ClN₃S

CAS Number:

357649-93-5

Molecular Weight:

291.80

NACRES:

NA.77

PubChem Substance ID:

329775211

UNSPSC Code:

12352200

MDL number:

MFCD02307488

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

Clc1ccc(cc1)-c2csc(N\N=C3\CCCC3)n2

InChI

1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18)

InChI key

YYTHPXHGWSAKIZ-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

General description

CPTH2 ((3-methylcyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl]hydrazone)) inhibits histone acetyltransferase functionality and reduces acetylation of histone H3 and H4. CPTH2 promotes apoptosis in lymphoma cell lines. It may serve as an anticancer agent. CPTH2 inhibits α-tubulin acetylation and modulates autophagic pathway in human acute myeloid leukemia cell lines.

Application

CPTH2 has been used for the inhibition of histone acetyltransferase in cortical cultures, bud cells and natural killer T cells (iNKT).

Biochem/physiol Actions

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network.

CPTH2 is a histone acetyltransferase (HAT) inhibitor modulating the Gcn5 network. Histone Acetyltransferase (HAT) inhibitor modulating Gcn5 network. Histone acetyltransferases (HATs) act as transcriptional coactivators. Histone acetylation plays an important role in regulating the chromatin structure and is tightly regulated by two classes of enzyme, histone acetyltransferases (HAT) and histone deacetylases (HDAC). Deregulated HAT and HDAC activity plays a role in the development of a range of cancers. Consequently, inhibitors of these enzymes have potential as anticancer agents.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A novel histone acetyltransferase inhibitor modulating Gcn5 network: cyclopentylidene-[4-(4?-chlorophenyl) thiazol-2-yl) hydrazone

Chimenti F, et al.

Journal of Medicinal Chemistry, 52(2), 530-536 (2008)

Epigenetic profiling reveals a developmental decrease in promoter accessibility during cortical maturation in vivo

Venkatesh I, et al.

Neuroepigenetics, 8, 19-26 (2016)

The thiazole derivative CPTH6 impairs autophagy

Ragazzoni Y, et al.

Cell Death & Disease, 4(3), e524-e524 (2013)

The lysine acetyltransferase GCN5 is required for iNKT cell development through EGR2 acetylation

Wang Y, et al.

Cell Reports, 20(3), 600-612 (2017)

CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells

Trisciuoglio D, et al.

Clinical Cancer Research, 18(2), 475-486 (2012)

View All Related Papers

Articles

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

Global Trade Item Number

SKU	GTIN
C9873-25MG	04061832631899
C9873-5MG	04061832631905

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service