C9915
ω-Conotoxin GVIA
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C120H182N38O43S6
CAS Number:
Molecular Weight:
3037.35
UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
Quality Level
assay
≥97% (HPLC)
form
powder
composition
Peptide content, ~70%
storage temp.
−20°C
Gene Information
human ... CACNA1B(774)
mouse ... CACNA1B(12287)
rat ... CACNA1B(257648)
Application
ω-Conotoxin GVIA has been used as an antagonist for N-type calcium channel (CaV2.2) in various studies.
Powerful probe for exploring the vertebrate pre-synaptic terminal.
Biochem/physiol Actions
ω-Conotoxin GVIA is a 27 amino acid neurotoxin containing three disulfide bonds. It inhibits central neurotransmitter release and also exhibits antihypertensive, analgesic and neuroprotective activities.
Blocks specific voltage-dependent N-type Ca2+ channels in neurons, but not in muscle; does not bind to either the dihydropyridine or verapamil binding sites; peptide first isolated from the marine snail Conus geographus L.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
高风险级别生物产品--毒素类产品
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Related Content
Instructions
Inhibition of central neurotransmitter release by omega-conotoxin GVIA, a peptide modulator of the N-type voltage-sensitive calcium channel
Dooley DJ, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 336(4), 467-470 (1987)
Precursor structure of omega-conotoxin GVIA determined from a cDNA clone
Colledge CJ, et al.
Toxicon, 30(9), 1111-1116 (1992)
Angela R Wild et al.
Cell reports, 26(13), 3537-3550 (2019-03-28)
Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the cell
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C9915-.5MG | 04061833420348 |
| C9915-.1MG | 04061833420331 |