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CRISPR
CRISPR/Cas9 Products and Services
Design and order CRISPR gRNA, Cas9, screening libraries, controls and companion products. Formats include plant, lentivirus, IVT-RNA, plasmid, synthetic, and protein.
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Synthetic CRISPR, crRNA, tracrRNA, CRISPR, CRISPRs, Cas9, Crispr RNA, Crispr/Cas System
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Thomas Gaj et al.
Trends in biotechnology, 31(7), 397-405 (2013-05-15)
Zinc-finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) comprise a powerful class of tools that are redefining the boundaries of biological research. These chimeric nucleases are composed of programmable, sequence-specific DNA-binding modules linked to a nonspecific DNA cleavage domain.
Takehito Kaneko et al.
Scientific reports, 4, 6382-6382 (2014-10-02)
Engineered endonucleases, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system, provide a powerful approach for genome editing in animals. However, the microinjection of endonucleases into embryos requires
Marian L Burr et al.
Cancer cell, 36(4), 385-401 (2019-10-01)
Loss of MHC class I (MHC-I) antigen presentation in cancer cells can elicit immunotherapy resistance. A genome-wide CRISPR/Cas9 screen identified an evolutionarily conserved function of polycomb repressive complex 2 (PRC2) that mediates coordinated transcriptional silencing of the MHC-I antigen processing
Hirotaka Ebina et al.
Scientific reports, 3, 2510-2510 (2013-08-27)
Even though highly active anti-retroviral therapy is able to keep HIV-1 replication under control, the virus can lie in a dormant state within the host genome, known as a latent reservoir, and poses a threat to re-emerge at any time.
Le Cong et al.
Science (New York, N.Y.), 339(6121), 819-823 (2013-01-05)
Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. We engineered two different
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