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Merck
CN

D0540

DNQX

≥98% (TLC), kainate, quisqualate (non-NMDA) glutamate receptor antagonist, powder

Synonym(s):

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

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About This Item

Empirical Formula (Hill Notation):
C8H4N4O6
CAS Number:
2379-57-9
Molecular Weight:
252.14
UNSPSC Code:
51111800
PubChem Substance ID:
24277973
NACRES:
NA.77
MDL number:
MFCD00069257

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Product Name

DNQX, ≥98% (TLC)

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O

InChI key

RWVIMCIPOAXUDG-UHFFFAOYSA-N

InChI

1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

assay

≥98% (TLC)

form

powder

Quality Level

200

Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)

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Application

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.

Biochem/physiol Actions

A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.
DNQX is a quinoxaline derivative.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Certificates of Analysis (COA)

Lot/Batch Number
0000406501
0000406502
0000406501
0000406502
0000356660

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J Waider et al.
Translational psychiatry, 7(10), e1246-e1246 (2017-10-04)
Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety disorders. Here we investigate the influence of constitutively deficient 5-HT synthesis on stressor-related anxiety-like behaviors using Tryptophan hydroxylase 2 (Tph2) mutant mice.
Differential Desensitization Observed at Multiple Effectors of Somatic mu-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity
Fox PD and Hentges ST
The Journal of Neuroscience, 37(36), 8667-8677 (2017)
Rei Yamada et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)
Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus
Focal activation of neuronal circuits induced by microstimulation in the visual cortex
Tanaka Y, et al.
Journal of Neural Engineering, 16(3), 036007-036007 (2019)
The mouse pulvinar nucleus links the lateral extrastriate cortex, striatum, and amygdala
Zhou N, et al.
The Journal of Neuroscience, 38(2), 347-362 (2018)
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