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D0540

DNQX

Name: DNQX
Brand: SIGMA

≥98% (TLC), kainate, quisqualate (non-NMDA) glutamate receptor antagonist, powder

Synonym(s):

6,7-Dinitroquinoxaline-2,3(1H,4H)-dione

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About This Item

Empirical Formula (Hill Notation):

C₈H₄N₄O₆

CAS Number:

2379-57-9

Molecular Weight:

252.14

UNSPSC Code:

51111800

PubChem Substance ID:

24277973

NACRES:

NA.77

MDL number:

MFCD00069257

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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Product Name

DNQX, ≥98% (TLC)

Quality Level

200

assay

≥98% (TLC)

form

powder

SMILES string

[O-][N+](=O)c1cc2NC(=O)C(=O)Nc2cc1[N+]([O-])=O

InChI

1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14)

InChI key

RWVIMCIPOAXUDG-UHFFFAOYSA-N

Gene Information

human ... GRIA1(2890), GRIA2(2891), GRIK1(2897), GRIK2(2898), GRIK3(2899), GRIK4(2900), GRIK5(2901)
mouse ... Gria1(14799)
rat ... Gria1(50592), Grik1(29559), Grik4(24406), Grin2a(24409)

Related Categories

Bioactive Small Molecules

Application

DNQX has been used to block N-Methyl-D-aspartic acid (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in various experiments.

Biochem/physiol Actions

DNQX is a quinoxaline derivative.

A competitive kainate, quisqualate (non-NMDA) glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Focal activation of neuronal circuits induced by microstimulation in the visual cortex

Tanaka Y, et al.

Journal of Neural Engineering, 16(3), 036007-036007 (2019)

The cooperation of sustained and phasic inhibitions increases the contrast of ITD-tuning in low-frequency neurons of the chick nucleus laminaris.

Rei Yamada et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(9), 3927-3938 (2013-03-01)

Neurons in the nucleus laminaris (NL) of birds detect the coincidence of binaural excitatory inputs from the nucleus magnocellularis (NM) on both sides and process the interaural time differences (ITDs) for sound localization. Sustained inhibition from the superior olivary nucleus

The mouse pulvinar nucleus links the lateral extrastriate cortex, striatum, and amygdala

Zhou N, et al.

The Journal of Neuroscience, 38(2), 347-362 (2018)

Optogenetic Mapping of Intracortical Circuits Originating from Semilunar Cells in the Piriform Cortex.

Julian M C Choy et al.

Cerebral cortex (New York, N.Y. : 1991), 27(1), 589-601 (2015-10-28)

Despite its comparatively simple trilaminar architecture, the primary olfactory (piriform) cortex of mammals is capable of performing sophisticated sensory processing, an ability that is thought to depend critically on its extensive associational (intracortical) excitatory circuits. Here, we used a novel

Differential Desensitization Observed at Multiple Effectors of Somatic mu-Opioid Receptors Underlies Sustained Agonist-Mediated Inhibition of Proopiomelanocortin Neuron Activity

Fox PD and Hentges ST

The Journal of Neuroscience, 37(36), 8667-8677 (2017)

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Global Trade Item Number

SKU	GTIN
D0540-25MG	04061832090146
D0540-50MG	04061833557839

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