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Merck
CN

D0633

7-(2,3-Dihydroxypropyl)theophylline

PDE inhibitor, powder

Synonym(s):

7-(2,3-Dihydroxypropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, Diprophylline, Dyphylline

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About This Item

Empirical Formula (Hill Notation):
C10H14N4O4
CAS Number:
479-18-5
Molecular Weight:
254.24
NACRES:
NA.77
PubChem Substance ID:
24893280
UNSPSC Code:
41106305
EC Number:
207-526-1
MDL number:
MFCD00005759
Beilstein/REAXYS Number:
284563

Key Documents

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Product Name

7-(2,3-Dihydroxypropyl)theophylline,

InChI key

KSCFJBIXMNOVSH-UHFFFAOYSA-N

InChI

1S/C10H14N4O4/c1-12-8-7(9(17)13(2)10(12)18)14(5-11-8)3-6(16)4-15/h5-6,15-16H,3-4H2,1-2H3

SMILES string

CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O

form

powder

mp

161-162 °C (lit.)

Quality Level

200

Gene Information

human ... PDE3A(5139), PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

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Biochem/physiol Actions

7-(2,3-Dihydroxypropyl)theophylline is also called as dyphylline. Dyphylline serves as a bronchodilator and aids in better air flow through the lungs. It reduces the symptoms of chronic lung disorder such as asthma and bronchitis.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000498656
0000490523
0000490523
0000479989
0000479989

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The AARP Guide to Pills: Essential Information on More Than 1,200 Prescription and Nonprescription Medicines, Including Generics, 302-302 (2006)
Mario Grassi et al.
International journal of pharmaceutics, 276(1-2), 107-114 (2004-04-29)
A mathematical model able to describe the release kinetics of two model drugs (Diprophylline and Theophylline) from partially coated hydroxypropylmethylcellulose (HPMC, Methocel) K4M) matrices is presented. As solvent interaction with the system and drug release can only take place in
Joshua Müller et al.
Journal of pharmaceutical and biomedical analysis, 53(4), 884-894 (2010-07-20)
A multivariate model was constructed by correlating Raman spectral data with coated amount of the API diprophylline using Partial Least Squares. In agreement with ICH guideline Q2 the method was validated in order to achieve the requirement of demonstrating that
Therapeutic Drug Monitoring and Toxicology by Liquid Chromatography (2017)
F Siepmann et al.
Journal of controlled release : official journal of the Controlled Release Society, 141(2), 216-222 (2009-09-10)
Kollidon SR-based matrix tablets containing various amounts of diprophylline were prepared and thoroughly characterized in vitro. This includes drug release measurements in 0.1M HCl and phosphate buffer pH 7.4, monitoring of changes in the tablet's height and diameter, morphology as
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