D0770
2′-Deoxyguanylyl(3′→5′)-2′-deoxyguanosine sodium salt
≥98%
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About This Item
Linear Formula:
C20H24N10O10PNa
CAS Number:
Molecular Weight:
618.43
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
assay
≥98%
storage temp.
−20°C
SMILES string
[Na].NC1=NC(=O)c2ncn(C3CC(O)C(COP(O)(=O)OC4CC(OC4CO)n5cnc6C(=O)N=C(N)Nc56)O3)c2N1
Application
2′-Deoxyguanylyl(3γ→5γ)-2′-deoxyguanosine is a dinucleotide d(GpG) construct used in conjunction with other di- tri- and other oligonucleotides as a model compounds to study the physiochemical interactions of various metal ions and other compounds with DNA structure.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Electron attachment to hydrated oligonucleotide dimers: guanylyl-3′,5′-cytidine and cytidylyl-3′,5′-guanosine.
Gu J, Xie Y, Schaefer HF 3rd.
Chemistry (Easton), 16, 5089-5096 (2010)
Bernd Knobloch et al.
Organic & biomolecular chemistry, 4(6), 1085-1090 (2006-03-10)
The dinucleotide d(pGpG) is an often employed DNA model to study various kinds of interactions between DNA and metal ions, but its acid-base properties were not yet described in detail. In this study the six deprotonation reactions of H4[d(pGpG)]+ are
Elizabeth F Day et al.
Rapid communications in mass spectrometry : RCM, 21(6), 903-910 (2007-02-23)
Dirhenium adducts of purine dinucleotides were identified by mass spectrometry. In consecutive studies, Re(2)(O(2)C(2)H(3))(2)Cl(4) . 2H(2)O was reacted with 2'-deoxyguanylyl(3'-->5')-2'-deoxyguanosine (dGpG) and 2'-deoxyadenylyl(3'-->5')-2'-deoxyguanosine (dApG) in H(2)O or D(2)O. These reactions were monitored to identify novel dinuclear rhenium:dinucleotide complexes as confirmed
Carla P Da Costa et al.
Inorganic chemistry, 42(11), 3475-3482 (2003-05-28)
The acidity constants of guanylyl(3'-->5')guanosine (GpG(-)) and 2'-deoxyguanylyl(3'-->5')-2'-deoxyguanosine [d(GpG)(-)] for the deprotonation of their (N1)H sites were measured by potentiometric pH titrations in aqueous solution (25 degrees C; I = 0.1 M, NaNO(3)). The same method was used for the
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