D0776
2′-Deoxycytidine hydrochloride
BioReagent, suitable for cell culture
Synonym(s):
1-(2-Deoxy-β-D-ribofuranosyl)cytosine hydrochloride, Cytosine deoxyriboside hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C9H13N3O4 · HCl
CAS Number:
Molecular Weight:
263.68
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
223-639-9
Beilstein/REAXYS Number:
3576124
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
biological source
synthetic
Quality Level
product line
BioReagent
assay
≥99% (HPLC)
form
powder
technique(s)
cell culture | mammalian: suitable
solubility
water: 50 mg/mL, clear, colorless
SMILES string
Cl[H].NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
InChI
1S/C9H13N3O4.ClH/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8;/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15);1H/t5-,6+,8+;/m0./s1
InChI key
LTKCXZGFJFAPLY-OERIEOFYSA-N
Application
2′-Deoxycytidine hydrochloride has been used:
- as a deoxyribonucleoside component in the basal medium to study its effects on Bacillus mojavensis′s anaerobic growth
- in the infectivity assay of monocyte-derived macrophages by human immunodeficiency virus 1 (HIV-1)
- in nucleoside supplementation for the synchronization of human retinal pigment epithelial-1 (RPE-1) cells in G1 phase
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Md Maminur Rahman et al.
The Journal of biological chemistry, 295(51), 17460-17475 (2021-01-18)
Homologous recombination (HR) repairs DNA double-strand breaks using intact homologous sequences as template DNA. Broken DNA and intact homologous sequences form joint molecules (JMs), including Holliday junctions (HJs), as HR intermediates. HJs are resolved to form crossover and noncrossover products.
Fuxia Li et al.
American journal of cancer research, 10(3), 908-924 (2020-04-09)
Epithelial ovarian cancer is characterized by universal TP53 mutations, which result in G1/S checkpoint deficiencies. Therefore, it is hypothesized that the abrogation of the G2/M checkpoint with Wee1 inhibitor might preferentially sensitize TP53-defective ovarian cancer cells. Given the extremely high
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| D0776-1G | 04061833558058 |
| D0776-250MG | 04061833558065 |