D0947
Dihydrotanshinone I
≥98% (HPLC)
Synonym(s):
Dihydrotanshinone I, (-)-Dihydrotanshinone I, 15,16-Dihydrotanshinone I
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About This Item
Empirical Formula (Hill Notation):
C18H14O3
CAS Number:
Molecular Weight:
278.30
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
biological source
Salvia miltiorrhiza
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
red
solubility
ethanol: 1 mg/mL, clear, orange to red
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O
InChI
1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
InChI key
HARGZZNYNSYSGJ-JTQLQIEISA-N
General description
DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.
Application
Dihydrotanshinone I (DHTS) has been used:
- to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
- as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
- as a potential SARS-CoV-2 papain-like protease (PLpro) inhibitor
- as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
- as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)
Biochem/physiol Actions
Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.
Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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