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D122

Domperidone

Name: Domperidone
Brand: SIGMA

≥98% (HPLC), Dopamine D2 receptor antagonist, powder

Synonym(s):

4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine

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About This Item

Empirical Formula (Hill Notation):

C₂₂H₂₄ClN₅O₂

CAS Number:

57808-66-9

Molecular Weight:

425.91

NACRES:

NA.77

PubChem Substance ID:

24277911

UNSPSC Code:

12352200

EC Number:

260-968-7

MDL number:

MFCD00069256

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

Domperidone, powder, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: >10 mg/mL, 0.1 M HCl: soluble, 0.1 M NaOH: slightly soluble, H₂O: insoluble

originator

Johnson & Johnson

SMILES string

Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1

InChI

1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30)

InChI key

FGXWKSZFVQUSTL-UHFFFAOYSA-N

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), KCNH2(3757)
rat ... Drd1a(24316), Drd2(24318), Drd3(29238), Htr3a(79246)

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Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08

signalword

Warning

hcodes

H361fd

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000353517

0000523132

0000523134

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Domperidone, a specific in vitro dopamine antagonist, devoid of in vivo central dopaminergic activity.

P M Laduron et al.

Biochemical pharmacology, 28(14), 2161-2165 (1979-07-15)

Domperidone: limited benefits with significant risk for sudden cardiac death.

Luc M Hondeghem

Journal of cardiovascular pharmacology, 61(3), 218-225 (2012-11-29)

Domperidone (antinausea/vomiting agent) was recently shown by several groups to increase sudden cardiac death (SCD). Drug-induced disturbances of cardiac repolarization may be a major mechanism. Experiments were executed in isolated female rabbit hearts perfused for 150 minutes with domperidone 30

Should domperidone be used for the treatment of gastro-oesophageal reflux in children? Systematic review of randomized controlled trials in children aged 1 month to 11 years old.

D S Pritchard et al.

British journal of clinical pharmacology, 59(6), 725-729 (2005-06-14)

To determine whether there is robust evidence of efficacy for domperidone in reducing the symptoms of gastro-oesophageal reflux (GOR) and gastro-oesophageal reflux disease (GORD) in children. Systematic review of randomized controlled trials (RCTs). A search was made of the Cochrane

Domperidone, a new dopamine antagonist.

M C Champion et al.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 135(5), 457-461 (1986-09-01)

Domperidone is a dopamine antagonist that has recently been released in Canada. Unlike metoclopramide hydrochloride, the other available dopamine antagonist, it does not readily enter the central nervous system. Domperidone acts as both an antiemetic and an upper gastrointestinal tract

Domperidone: review of pharmacology and clinical applications in gastroenterology.

Savio C Reddymasu et al.

The American journal of gastroenterology, 102(9), 2036-2045 (2007-05-10)

Domperidone is a dopamine-2 receptor antagonist. It acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine. Unlike metoclopramide, it does not cause any adverse

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Global Trade Item Number

SKU	GTIN
D122-25MG	04061833559000
D122-500MG	04061833559017
D122-100MG	04061833558997

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