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D127

Dextrorphan tartrate

Name: Dextrorphan tartrate
Brand: SIGMA

NMDA-receptor antagonist, powder

Synonym(s):

(+)-3-Hydroxy-N-methylmorphinan (+)-tartrate salt, Dextrorphan D-tartrate

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₃NO · C₄H₆O₆

CAS Number:

143-98-6

Molecular Weight:

407.46

MDL number:

MFCD00151495

UNSPSC Code:

12352200

PubChem Substance ID:

24277974

NACRES:

NA.32

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Product Name

Dextrorphan tartrate, powder

description

Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

Quality Level

200

form

powder

drug control

Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

color

white

solubility

H₂O: >10 mg/mL

SMILES string

O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34

InChI

1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m10/s1

InChI key

RWTWIZDKEIWLKQ-FEBOIHDFSA-N

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

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Bioactive Small Molecules

Application

Dextrorphan tartrate has been used to study its effects on blood glucose levels by targeting pancreatic islets.

Biochem/physiol Actions

Dextrorphan is a noncompetitive NMDA glutamate receptor antagonist that attenuates glutamate neurotoxicity in cortical cell cultures.

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品

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The role of excitatory amino acids and NMDA receptors in traumatic brain injury.

A I Faden et al.

Science (New York, N.Y.), 244(4906), 798-800 (1989-05-19)

Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with

Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets

Okka S, et al.

Cell Chemical Biology (2021)

Global Trade Item Number

SKU	GTIN
D127-500MG	04061833559222

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