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Merck
CN

D127

Dextrorphan tartrate

NMDA-receptor antagonist, powder

Synonym(s):

(+)-3-Hydroxy-N-methylmorphinan (+)-tartrate salt, Dextrorphan D-tartrate

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About This Item

Empirical Formula (Hill Notation):
C17H23NO · C4H6O6
CAS Number:
143-98-6
Molecular Weight:
407.46
MDL number:
MFCD00151495
UNSPSC Code:
12352200
PubChem Substance ID:
24277974
NACRES:
NA.32

Key Documents

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Product Name

Dextrorphan tartrate, powder

SMILES string

O[C@@H]([C@H](O)C(O)=O)C(O)=O.CN1CC[C@@]23CCCC[C@@H]2[C@@H]1Cc4ccc(O)cc34

InChI

1S/C17H23NO.C4H6O6/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17;5-1(3(7)8)2(6)4(9)10/h5-6,11,14,16,19H,2-4,7-10H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t14-,16+,17+;1-,2-/m10/s1

InChI key

RWTWIZDKEIWLKQ-FEBOIHDFSA-N

description

Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

form

powder

drug control

Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet

color

white

solubility

H2O: >10 mg/mL

Quality Level

200

Gene Information

human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)

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Application

Dextrorphan tartrate has been used to study its effects on blood glucose levels by targeting pancreatic islets.

Biochem/physiol Actions

Dextrorphan is a noncompetitive NMDA glutamate receptor antagonist that attenuates glutamate neurotoxicity in cortical cell cultures.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000405807
0000366966
0000327663
0000405807
0000366966

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A I Faden et al.
Science (New York, N.Y.), 244(4906), 798-800 (1989-05-19)
Brain injury induced by fluid percussion in rats caused a marked elevation in extracellular glutamate and aspartate adjacent to the trauma site. This increase in excitatory amino acids was related to the severity of the injury and was associated with
Peripherally active dextromethorphan derivatives lower blood glucose levels by targeting pancreatic islets
Okka S, et al.
Cell Chemical Biology (2021)

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