Key Documents

View All Documentation

D1641

Dihydrocytochalasin B

Name: Dihydrocytochalasin B
Brand: SIGMA

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₂₉H₃₉NO₅

CAS Number:

39156-67-7

Molecular Weight:

481.62

NACRES:

NA.32

PubChem Substance ID:

24893505

UNSPSC Code:

12352202

EC Number:

254-324-4

MDL number:

MFCD12910542

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

form

powder

Quality Level

200

storage temp.

−20°C

SMILES string

C[C@@H]1CCC[C@@H](O)CCC(=O)O[C@]23[C@@H](\C=C\C1)[C@H](O)C(=C)[C@@H](C)[C@H]2[C@H](Cc4ccccc4)NC3=O

InChI

1S/C29H39NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14,18-19,22-24,26-27,31,33H,3,7,9-10,13,15-17H2,1-2H3,(H,30,34)/b14-8+/t18-,19-,22-,23+,24+,26+,27-,29-/m1/s1

InChI key

WIULKAASLBZREV-RXPQEOCGSA-N

Application

Marker for high affinity cytochalasin B binding sites.

Biochem/physiol Actions

Effect on cell motility and morphology similar to that of cytochalasin B; does not inhibit glucose transport.

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300 + H310 + H330,H351

pcodes

P202 - P260 - P264 - P280 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Carc. 2

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

高风险级别生物产品--毒素类产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Chemical induction of mitotic checkpoint override in mammalian cells results in aneuploidy following a transient tetraploid state.

P R Andreassen et al.

Mutation research, 372(2), 181-194 (1996-12-01)

Populations of tetraploid cells are found in a variety of human tumours where they may act as precursors of aneuploidy and tumorigenesis. Here we demonstrate the drug induction of tetraploid cells at mitosis by interference with cell cycle checkpoints and

Neutrophils can adhere via alpha4beta1-integrin under flow conditions.

P H Reinhardt et al.

Blood, 89(10), 3837-3846 (1997-05-15)

In this study we investigated the possibility that an alternative pathway exists for neutrophil recruitment, namely an alpha4beta1-dependent pathway. A parallel plate chamber was used to investigate whether neutrophils could tether, roll, and adhere to tumor necrosis factor alpha (TNF

Fast inactivation of a brain K+ channel composed of Kv1.1 and Kvbeta1.1 subunits modulated by G protein beta gamma subunits.

J Jing et al.

The EMBO journal, 18(5), 1245-1256 (1999-03-04)

Modulation of A-type voltage-gated K+ channels can produce plastic changes in neuronal signaling. It was shown that the delayed-rectifier Kv1.1 channel can be converted to A-type upon association with Kvbeta1.1 subunits; the conversion is only partial and is modulated by

Actin polymerization is required for negative feedback regulation of epidermal growth factor-induced signal transduction.

P J Rijken et al.

Experimental cell research, 243(2), 254-262 (1998-09-23)

Epidermal growth factor (EGF) induces rapid actin filament assembly in the membrane skeleton of a variety of cells. To investigate the significance of this process for signal transduction, actin polymerization is inhibited by dihydrocytochalasin B (CB). CB almost completely abolishes

Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts.

Lucia Formigli et al.

Journal of cellular physiology, 211(2), 296-306 (2007-02-14)

In the present study, we investigated the functional interaction between stress fibers (SFs) and stretch-activated channels (SACs) and its possible role in the regulation of myoblast differentiation induced by switch to differentiation culture in the presence or absence of sphingosine

View All Related Papers

Global Trade Item Number

SKU	GTIN
D1641-1MG	04061826682340
D1641-5MG	04061833270363

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service