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D184

Diethylamine NONOate sodium salt hydrate

Name: Diethylamine NONOate sodium salt hydrate
Brand: SIGMA

≥97% (NMR), crystalline, nitrix oxide donor

Synonym(s):

1,1-Diethyl-2-hydroxy-2-nitroso-hydrazine sodium, 2-(N,N-Diethylamino)-diazenolate 2-oxide sodium salt hydrate, DEA NONOate sodium salt hydrate, Diethylamine/nitric oxide complex sodium salt hydrate

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About This Item

Linear Formula:

(CH₃CH₂)₂N–N(N=O)O^- Na⁺ xH₂O

CAS Number:

1314960-89-8

Molecular Weight:

155.13 (anhydrous basis)

UNSPSC Code:

12352116

PubChem Substance ID:

24893276

NACRES:

NA.77

MDL number:

MFCD11045976

Assay:

≥97% (NMR)

Form:

crystalline

Quality level:

100

Storage condition:

desiccated, protect from light

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Product Name

Diethylamine NONOate sodium salt hydrate, ≥97% (NMR)

Quality Level

100

assay

≥97% (NMR)

form

crystalline

storage condition

desiccated, protect from light

color

white

mp

45 °C (lit.)

solubility

H₂O: >10 mg/mL, methanol: >25 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

O.[Na+].CCN(CC)N([O-])N=O

InChI

1S/C4H10N3O2.Na.H2O/c1-3-6(4-2)7(9)5-8;;/h3-4H2,1-2H3;;1H2/q-1;+1;

InChI key

BVCZSYKIXSAMOT-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecules

Application

Diethylamine NONOate sodium salt hydrate has been used as a nitric oxide donor to evaluate endothelium-independent dilation. It has also been used to determine the level of nitric oxide in cell free systems.

Biochem/physiol Actions

Diethylamine NONOate is a complex of diethylamine with nitric oxide used to generate a controlled release of nitric oxide in solution.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000507055

0000493070

0000461201

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Nitric oxide-dependent long-term depression but not endocannabinoid-mediated long-term potentiation is crucial for visual recognition memory.

Francesco Tamagnini et al.

The Journal of physiology, 591(16), 3963-3979 (2013-05-15)

Synaptic plasticity in perirhinal cortex is essential for recognition memory. Nitric oxide and endocannabinoids (eCBs), which are produced in the postsynaptic cell and act on the presynaptic terminal, are implicated in mechanisms of long-term potentiation (LTP) and long-term depression (LTD)

The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation.

Nina Jeppesen Edin et al.

Journal of radiation research, 54(6), 1015-1028 (2013-05-21)

In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025)

Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson?s Disease Etiopathology

Wilkaniec A, et al.

Molecular Neurobiology, 56(1), 125-140 (2019)

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Articles

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

Global Trade Item Number

SKU	GTIN
D184-50MG	04061833261309
D184-25MG	04061833560877

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