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D1881

Dexamethasone 21-acetate

Name: Dexamethasone 21-acetate
Brand: SIGMA

≥99%, dexamethasone derivative , powder

Synonym(s):

9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₁FO₆

CAS Number:

1177-87-3

Molecular Weight:

434.50

NACRES:

NA.77

PubChem Substance ID:

24893562

UNSPSC Code:

51422333

EC Number:

214-646-8

MDL number:

MFCD00027407

Beilstein/REAXYS Number:

2342608

Assay:

≥99%

Form:

powder

Quality level:

100

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Product Name

Dexamethasone 21-acetate, ≥99%

Quality Level

100

assay

≥99%

form

powder

storage temp.

2-8°C

SMILES string

[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O

InChI

1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1

InChI key

AKUJBENLRBOFTD-RPRRAYFGSA-N

Gene Information

human ... NR3C1(2908)

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Related Categories

Bioactive Small Molecules

Application

Dexamethasone 21-acetate has been used:

as a component of the induction medium for the treatment of mice preadipocytes (5A) cells
as a synthetic glucocorticoid to study its effects on the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in placentas of human and mice
as a component of the complete medium for the culturing of porcine hepatocytes

Biochem/physiol Actions

Dexamethasone 21-acetate or dexamethasone acetate is a derivative of dexamethasone. It is a hydrophobic drug. Dexamethasone is a glucocorticoid possessing anti-inflammatory activity.

pictograms

GHS08

signalword

Danger

hcodes

H360FD

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

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Dexamethasone measurement during low-dose suppression test for suspected hypercortisolism: threshold development with and validation.

F Ceccato et al.

Journal of endocrinological investigation, 43(8), 1105-1113 (2020-02-16)

Dexamethasone Suppression Test (DST), recommended for Cushing's Syndrome (CS) diagnosis, explores the pituitary feedback to glucocorticoids. Its diagnostic accuracy could be affected by dexamethasone bioavailability, and therefore, we have developed and validated a dexamethasone threshold after 1-mg DST. We studied

Impact of High Fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels

Carrer1 A, et al.

The Journal of Biological Chemistry, 5(1-2), 487-487 (2017)

Culture of porcine hepatocytes or bile duct epithelial cells by inductive serum-free media

Caperna T J, et al.

In Vitro Cellular & Developmental Biology. Animal, 47(3), 218-233 (2011)

Expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and peroxiredoxin 6 (Prdx6) proteins in healthy and pathologic placentas of human and rat

Acar N, et al.

Acta Histochemica, 116(8), 1289-1300 (2014)

In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system

Wang M T, et al.

International journal of nanomedicine, 5(1-2), 487-487 (2010)

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Global Trade Item Number

SKU	GTIN
D1881-100MG	04061833560983
D1881-1G	04061833560990
D1881-500MG	04061832631912

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