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D2043

Defensin HNP-1 human

≥80% (HPLC)

Synonym(s):

Neutrophil Peptide-1

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About This Item

Empirical Formula (Hill Notation):
C150H222N44O38S6
CAS Number:
99287-08-8
Molecular Weight:
3442.03
NACRES:
NA.32
PubChem Substance ID:
329798727
UNSPSC Code:
12352202
MDL number:
MFCD00214572
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Quality Segment

200

assay

≥80% (HPLC)

form

powder

composition

Peptide content, ~70%

solubility

water: 1 mg/mL, clear, colorless

UniProt accession no.

P59665

antibiotic activity spectrum

fungi, mycobacteria, viruses

mode of action

cell membrane | interferes

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@H](Cc5c[nH]c6ccccc56)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc7ccc(O)cc7)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc8ccc(O)cc8)NC(=O)[C@H](CSSC[C@H](NC3=O)C(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N9CCC[C@H]9C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc%10ccc(O)cc%10)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](C)NC1=O)[C@@H](C)O)[C@@H](C)CC

InChI

1S/C150H222N44O38S6/c1-14-74(6)116-142(227)171-78(10)121(206)166-64-112(200)173-97(49-51-115(203)204)129(214)175-93(32-23-53-162-148(155)156)127(212)174-94(33-24-54-163-149(157)158)128(213)180-99(59-83-36-42-87(196)43-37-83)125(210)168-66-114(202)190-119(81(13)195)144(229)188-108-71-236-233-68-105-136(221)176-95(34-25-55-164-150(159)160)130(215)193-118(76(8)16-3)145(230)194-56-26-35-110(194)141(226)170-80(12)123(208)185-107(139(224)191-116)70-235-234-69-106(138(223)189-109(146(231)232)72-238-237-67-104(184-120(205)77(9)151)137(222)181-101(135(220)186-105)60-84-38-44-88(197)45-39-84)187-134(219)100(58-82-27-18-17-19-28-82)178-122(207)79(11)169-131(216)103(62-86-63-165-91-30-21-20-29-90(86)91)182-132(217)98(57-73(4)5)179-126(211)92(31-22-52-161-147(153)154)172-113(201)65-167-124(209)96(48-50-111(152)199)177-133(218)102(61-85-40-46-89(198)47-41-85)183-143(228)117(75(7)15-2)192-140(108)225/h17-21,27-30,36-47,63,73-81,92-110,116-119,165,195-198H,14-16,22-26,31-35,48-62,64-72,151H2,1-13H3,(H2,152,199)(H,166,206)(H,167,209)(H,168,210)(H,169,216)(H,170,226)(H,171,227)(H,172,201)(H,173,200)(H,174,212)(H,175,214)(H,176,221)(H,177,218)(H,178,207)(H,179,211)(H,180,213)(H,181,222)(H,182,217)(H,183,228)(H,184,205)(H,185,208)(H,186,220)(H,187,219)(H,188,229)(H,189,223)(H,190,202)(H,191,224)(H,192,225)(H,193,215)(H,203,204)(H,231,232)(H4,153,154,161)(H4,155,156,162)(H4,157,158,163)(H4,159,160,164)/t74-,75-,76-,77-,78-,79-,80-,81+,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,116-,117-,118-,119-/m0/s1

InChI key

KRJOFJHOZZPBKI-KSWODRSDSA-N

Gene Information

human ... DEFA1(1667)

General description

The α-defensin genes, such as DEFA1 (defensin alpha 1) and DEFA3 (defensin α 3) codes for HNP-1, 2 and 3 (human neutrophil peptides). This gene is mapped to human chromosome 8p23.1.
Chemical structure: peptide

Biochem/physiol Actions

Human neutrophil peptides (HNPs) is involved in endothelial cell dysfunction at the time of early atherosclerotic development. HNP 1−3 can regulate the growth of atherosclerosis. HNP 1−3 levels are usually high in inflammation, including sepsis and acute coronary vascular disorders.
This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this family are variably arginine-rich and share six conserved cysteine residues that participate in intramolecular disulfide bonds.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBC1825V
099K8739
029K8743
038K1653
029K1032

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Global Trade Item Number

SKUGTIN
D2043-25UG04061833561409