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Merck
CN

D2155

N-Dansyl-D-Ala-Gly-p-nitro-Phe-Gly

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C28H32N6O9S
CAS Number:
83960-27-4
Molecular Weight:
628.65
NACRES:
NA.32
PubChem Substance ID:
24893643
UNSPSC Code:
12352204
MDL number:
MFCD00133590

Key Documents

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Product Name

N-Dansyl-D-Ala-Gly-p-nitro-Phe-Gly, ≥95% (HPLC)

InChI

1S/C28H32N6O9S/c1-17(32-44(42,43)24-9-5-6-20-21(24)7-4-8-23(20)33(2)3)27(38)29-15-25(35)31-22(28(39)30-16-26(36)37)14-18-10-12-19(13-11-18)34(40)41/h4-13,17,22,32H,14-16H2,1-3H3,(H,29,38)(H,30,39)(H,31,35)(H,36,37)

SMILES string

CC(NS(=O)(=O)c1cccc2c(cccc12)N(C)C)C(=O)NCC(=O)NC(Cc3ccc(cc3)N(=O)=O)C(=O)NCC(O)=O

InChI key

MIHGGGACSSHXPY-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

solubility

methanol: 50 mg

storage temp.

−20°C

Quality Level

200

General description

Selective fluorogenic substrate for enkephalinase.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
071M5059
071M5059V
120K5132
120K5106
095F5820

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Hitoshi Nakagawa et al.
Hypertension (Dallas, Tex. : 1979), 77(6), 1931-1939 (2021-04-13)
[Figure: see text].
Rishi K Trivedi et al.
Journal of the American Heart Association, 7(5) (2018-03-05)
There is a paucity of data about the mechanisms by which sacubitril/valsartan (also known as LCZ696) improves outcomes in patients with heart failure. Specifically, the effects of sacubitril/valsartan on vascular function and NO bioavailability have not been investigated. We hypothesized
D Florentin et al.
Analytical biochemistry, 141(1), 62-69 (1984-08-15)
A fluorogenic peptide, dansyl-D-Ala-Gly-Phe(pNO2)-Gly (DAGNPG), was synthesized as a selective substrate for the neutral metalloendopeptidase (EC 3.4.24.11) involved in enkephalin metabolism. This enzyme, designated "enkephalinase," cleaves the Gly-Phe(pNO2) peptide bond of DAGNPG (V = 0.65 mumol/mg protein/min and Km =

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