D2390
Dacarbazine
antineoplastic purine analog
Synonym(s):
5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide, DTIC
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C6H10N6O
CAS Number:
Molecular Weight:
182.18
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
224-396-1
MDL number:
Quality Segment
form
powder or crystals
solubility
1 M HCl: 50 mg/mL
antibiotic activity spectrum
neoplastics
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
CN(C)\N=N\c1[nH]cnc1C(N)=O
InChI
1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+
InChI key
FDKXTQMXEQVLRF-ZHACJKMWSA-N
Application
Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents.
Biochem/physiol Actions
Dacarbazine is a purine analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). It is a synthetic triazine antineoplastic agent that exerts cytotoxic effects by acting as an alkylating agent and by inhibiting DNA synthesis and inducing apoptosis. It is known to induce hepatotoxicity in mice. Dacarbazine is not cell cycle-phase specific.
Other Notes
Keep container tightly closed in a dry and well-ventilated place.
Still not finding the right product?
Explore all of our products under Dacarbazine
signalword
Danger
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
No data available
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
hcodes
Hazard Classifications
Carc. 1B - Muta. 1B
flash_point_c
No data available
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.