D2396
Dimenhydrinate
Synonym(s):
N-(2-Diphenylmethoxyethyl)-N,N-dimethylammonium 8-chlorotheophyllinate
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About This Item
Empirical Formula (Hill Notation):
C17H21NO · C7H7ClN4O2
CAS Number:
Molecular Weight:
469.96
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
208-350-8
MDL number:
Form:
powder
Quality level:
InChI key
NFLLKCVHYJRNRH-UHFFFAOYSA-N
InChI
1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)
SMILES string
CN1C(=O)N(C)c2nc(Cl)[nH]c2C1=O.CN(C)CCOC(c3ccccc3)c4ccccc4
form
powder
Quality Level
Gene Information
human ... HRH1(3269)
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General description
Dimenhydrinate is a salt of antihistamine drugs, such as diphenhydramine and 8-chlorotheophylline. It has antiemetic properties. Dimenhydrinate is used to treat nausea and vomiting during pregnancy.
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Serge Gouin et al.
Pediatrics, 129(6), 1050-1055 (2012-05-16)
To evaluate the efficacy and safety of oral dimenhydrinate in the treatment of acute gastroenteritis. This was a randomized, double-blind, placebo-controlled trial conducted in the emergency department of a pediatric university-affiliated center. Children 1 to 12 years old who presented
Faisal Karmali et al.
Journal of vestibular research : equilibrium & orientation, 20(1), 31-43 (2010-06-18)
Commercial sub-orbital operators will soon offer the excitement of traveling to space to thousands of people. Based on previous experience in space flight and parabolic flight, sensorimotor disruptions in eye movements, postural stability, and motor coordination are likely in these
Gerard Nobel et al.
Brain research bulletin, 82(3-4), 193-200 (2010-04-17)
Motion sickness (MS) exaggerates body cooling during cold-water immersion. The aim of the present study was to investigate whether such MS-induced predisposition to hypothermia is influenced by two anti-MS drugs: the histamine-receptor blocker dimenhydrinate (DMH) and the muscarine-receptor blocker scopolamine
Matthias Voigt et al.
Journal of clinical anesthesia, 23(6), 461-468 (2011-09-14)
To evaluate strategies to treat postoperative nausea and vomiting (PONV) in patients undergoing elective breast surgery. Prospective, randomized, double-blinded, placebo-controlled trial. University-affiliated hospital. 480 patients with risk factors for PONV. Patients were randomized to three groups to receive an antiemetic
Ulrike Uhlig et al.
Pediatrics, 124(4), e622-e632 (2009-09-16)
Vomiting is a common symptom in children with infectious gastroenteritis. It contributes to fluid loss and is a limiting factor for oral rehydration therapy. Dimenhydrinate has traditionally been used for children with gastroenteritis in countries such as Canada and Germany.
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