D2571
DPPE hydrochloride
≥98% (HPLC)
Synonym(s):
BMS-217380-01, N,N-Diethyl-2-[4-(phenylmethyl) phenoxy]ethanamine hydrochloride, Tesmilifene hydrochloride, YMB1002, [2-(4-Benzyl-phenoxy)-ethyl]-diethyl-amine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C19H25NO·HCl
CAS Number:
Molecular Weight:
319.87
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white
solubility
H2O: 16 mg/mL
storage temp.
2-8°C
SMILES string
Cl.CCN(CC)CCOc1ccc(Cc2ccccc2)cc1
InChI
1S/C19H25NO.ClH/c1-3-20(4-2)14-15-21-19-12-10-18(11-13-19)16-17-8-6-5-7-9-17;/h5-13H,3-4,14-16H2,1-2H3;1H
InChI key
TXLHNFOLHRXMAU-UHFFFAOYSA-N
Biochem/physiol Actions
DPPE is a potent, selective ligand of the microsomal anti-estrogen binding site.
DPPE is a potent, selective ligand of the microsomal anti-estrogen binding site. DPPE is a tamoxifen derivataive that binds with high affinity to the anti-estrogen binding site, but unlike tamoxifen, does not bind to the estrogen receptor. DPPE sensitizes MDR tumor cells to chemotherapy and also inhibits histamine binding at the intracellular histamine site.
Features and Benefits
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Histidine decarboxylase and intracellular histamine in melanoma cells and in a T cell line.
A Falus et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 46 Suppl 1, S51-S52 (1997-03-01)
Jianhua Liu et al.
Breast cancer research and treatment, 100(3), 263-271 (2006-07-11)
DPPE (tesmilifene) plus doxorubicin (DOX) demonstrated a significant improvement in survival versus DOX in a phase III clinical trial in advanced breast cancer. However, DPPE is associated with unusual toxicity in the form of hallucinations, nausea and vomiting which were
Mark Vincent
Medical hypotheses, 66(4), 715-731 (2006-01-18)
Tesmilifene is a novel potentiator of chemotherapy which, when added to doxorubicin, achieved an unexpected and very large survival advantage over doxorubicin alone in a randomized trial in advanced breast cancer. This trial was unusual in that the early endpoints
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D2571-25MG | 04061832867052 |
| D2571-5MG | 04061832867069 |