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D2629

6-(Dimethylamino)purine

Name: 6-(Dimethylamino)purine
Brand: SIGMA

≥98%, synthetic (organic), powder

Synonym(s):

6-DMAP, N⁶,N⁶-Dimethyladenine

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About This Item

Empirical Formula (Hill Notation):

C₇H₉N₅

CAS Number:

938-55-6

Molecular Weight:

163.18

NACRES:

NA.51

PubChem Substance ID:

24893701

UNSPSC Code:

41106305

EC Number:

213-344-3

MDL number:

MFCD00005573

Beilstein/REAXYS Number:

7634

Assay:

≥98%

Biological source:

synthetic (organic)

Form:

powder

Solubility:

water: 50 mg/mL, clear to hazy, colorless to light yellow

Storage temp.:

−20°C

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Properties

Product Name

6-(Dimethylamino)purine, ≥98%

biological source

synthetic (organic)

Quality Segment

100

assay

≥98%

form

powder

mp

259-262 °C (lit.)

solubility

water: 50 mg/mL, clear to hazy, colorless to light yellow

storage temp.

−20°C

SMILES string

CN(C)c1ncnc2[nH]cnc12

InChI

1S/C7H9N5/c1-12(2)7-5-6(9-3-8-5)10-4-11-7/h3-4H,1-2H3,(H,8,9,10,11)

InChI key

BVIAOQMSVZHOJM-UHFFFAOYSA-N

Description

General description

6-(Dimethylamino)purine (6-DMAP) is a purine-based metabolite with two condensed heterocyclic rings and two methyl groups linked to the amino group of the purine unit of adenine.

Application

6-(Dimethylamino)purine has been used:

as a supplement in GR-1 aa medium (bovine medium) for parthenogenetic activation of bovine oocytes to study its potential for embryo development
in the activation step during the production of nuclear transfer embryos
as a supplement in HCR2aa medium to activate interspecies embryos derived from interspecies somatic cell nuclear transfer (iSCNT) technique

Biochem/physiol Actions

6-(Dimethylamino)purine (6-DMAP) is a protein kinase and cyclin-dependent kinase inhibitor. It acts as a secondary metabolite and mediates RNA modification. 6-DMAP is a potent cytokinetic inhibitor and is used in parthenogenesis and meiosis studies. It is also used to promote pronuclei formation in mammalian oocytes. 6-DMAP is a dual fluorescence molecule according to femtosecond fluorescence up-conversion spectroscopy studies.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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