D3196
Dipeptidyl Peptidase VIII human
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About This Item
NACRES:
NA.54
UNSPSC Code:
12352204
Specific activity:
≥20 units/μg protein
Recombinant:
expressed in Sf9 cells
Concentration:
≥0.08 mg/mL
recombinant
expressed in Sf9 cells
Quality Segment
form
solution
specific activity
≥20 units/μg protein
mol wt
100 kDa
concentration
≥0.08 mg/mL
shipped in
dry ice
storage temp.
−70°C
General description
Full length sequence with an N-terminal GST tag
Application
Human dipeptidyl peptidase VIII has been used in a study to identify ERGIC-53 as an intracellular transport receptor of α1-antitrypsin. Human dipeptidyl peptidase VIII has also been used in a study to investigate the cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex.
Biochem/physiol Actions
Dipeptidyl peptidase VIII (DPP8) is a 100 kDa monomeric protein expressed in the cytoplasm. It is a postproline dipeptidyl aminopeptidase that is homologous to DPPIV and fibroblast activation protein (FAP). It hydrolyzes Ala-Pro, Arg-Pro and Gly-Pro. DPP8 has a neutral pH optimum. It may be involved in T-cell activation and immune function as it is similar to DPPIV . It is upregulated during immune activation.
Physical form
Supplied as a solution in 40 mM Tris-HCL, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT and 20% glycerol.
Other Notes
One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| D3196-10UG | 04061832700489 |