D3566
Anti-DcR1 antibody produced in rabbit
~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-Decoy Receptor 1, Anti-LIT, Anti-TRAIL-R3, Anti-TRID
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About This Item
UNSPSC Code:
12352203
MDL number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~65 kDa
species reactivity
mouse, rat, human
concentration
~0.5 mg/mL
technique(s)
microarray: suitable, western blot: 0.5-1 μg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... TNFRSF10C(8794)
General description
DcR1 is found in most normal human tissue, but not in most cancer cell lines. It is a member of the TNF family of TRAIL (TNF-related apoptosis-induced ligand) receptors.
Immunogen
synthetic peptide corresponding to amino acids 111-123 at the extracellular domain of human DcR1 precursor.
Application
Anti-DcR1 antibody produced in rabbit is suitable for immunoblotting at a working concentration of 0.5-1μg/mL using human HeLa cells and mouse and rat liver tissue lysates.
Biochem/physiol Actions
DcR1 is a glycosylphosphatidylinositol-linked membrane protein that binds TRAIL (APO2 ligand). It acts as a decoy receptor and binds TRAIL to its extracellular TRAIL-binding domain, thus inhibiting TRAIL-mediated apoptosis. It does not have an intracellular death domain and, therefore, does not induce apoptosis.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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