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D3648

Diamide

Synonym(s):

1,1′-Azobis(N,N-dimethylformamide), N,N,N′,N′-Tetramethylazodicarboxamide, Azodicarboxylic acid bis(dimethylamide), Diazenedicarboxylic acid bis(N,N-dimethylamide), TMAD

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About This Item

Linear Formula:
(CH3)2NCON=NCON(CH3)2
CAS Number:
10465-78-8
Molecular Weight:
172.19
UNSPSC Code:
12352102
NACRES:
NA.22
PubChem Substance ID:
24278365
EC Number:
233-951-7
Beilstein/REAXYS Number:
1910409
MDL number:
MFCD00008318
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assay

≥98% (TLC)

Quality Segment

200

form

powder

mp

113-115 °C

solubility

water: 19.60-21.00 mg/mL, clear to slightly hazy, orange

storage temp.

−20°C

SMILES string

CN(C)C(=O)\N=N\C(=O)N(C)C

InChI

1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+

InChI key

VLSDXINSOMDCBK-BQYQJAHWSA-N

Application

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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