D4036
Dynorphin A Porcine Fragment 1-9
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C52H84N18O11
CAS Number:
Molecular Weight:
1137.34
UNSPSC Code:
12352200
MDL number:
SMILES string
CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
assay
≥97% (HPLC)
UniProt accession no.
storage temp.
−20°C
Gene Information
pig ... PDYN(445529)
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Biochem/physiol Actions
Potent κ-agonist
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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M Maruyama et al.
Brain research, 401(1), 14-22 (1987-01-13)
This paper describes the binding properties of [3H]peptidergic opioid ligands to binding sites solubilized from rat brain membranes by the treatment with 0.125% sodium glycodeoxycholate and 1 M NaCl. The highest amount of the specific binding of [3H]-[D-Ala2-, Met5]enkephalinamide was
P Slater et al.
Neuropeptides, 8(1), 71-76 (1986-07-01)
The autoradiographic distribution of kappa opioid binding sites was evaluated in sections of monkey brain using the selective ligand [3H]dynorphin1-9. Kappa receptors were highly concentrated in the deep layers of the cerebral cortex, the substantia nigra, the hippocampus and the
M G Gillan et al.
Journal of neurochemistry, 45(4), 1034-1042 (1985-10-01)
Following incubation of [3H]dynorphin A (1-8) and [3H]dynorphin A (1-9) with suspensions of guinea pig brain membranes, analysis of the supernatants by HPLC has shown that both peptides are degraded at 25 degrees C and at 0 degrees C. Bestatin
L Miller et al.
European journal of pharmacology, 116(1-2), 159-163 (1985-10-08)
The inhibitory action of dynorphin-(1-9) on the electrically stimulated mouse vas deferens was seen to be antagonised by the delta-selective opioid antagonist ICI 174864. The observed delta-receptor mediated responses were partially, but not totally, prevented by peptidase inhibitors which protect
X Ni et al.
Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns, 11(4), 258-261 (1995-07-01)
The lymphocyte response to Con A and IL-2 synthesis was clearly suppressed in rats after thermal injury. In burn rats, the cAMP content in lymphocytes was significantly increased, but cGMP level was not changed. The serum of burn rat could
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