D4071
5, 15-DPP
Synonym(s):
5,15-Diphenyl-21H,23H-porphine, 5,15-Diphenylporphyrin, 5,15-diphenyl-Porphine
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About This Item
Empirical Formula (Hill Notation):
C32H22N4
CAS Number:
Molecular Weight:
462.54
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Quality Segment
form
powder
SMILES string
c1ccc(cc1)-c2c3ccc(cc4ccc([nH]4)c(-c5ccccc5)c6ccc(cc7ccc2[nH]7)n6)n3
InChI
1S/C32H22N4/c1-3-7-21(8-4-1)31-27-15-11-23(33-27)19-25-13-17-29(35-25)32(22-9-5-2-6-10-22)30-18-14-26(36-30)20-24-12-16-28(31)34-24/h1-20,33,36H/b23-19-,24-20-,25-19-,26-20-,31-27-,31-28-,32-29-,32-30-
InChI key
FNNOEKVUXXVPAI-DUVOQLPESA-N
Application
5, 15-DPP has been used as a signal transducer and activator of transcription 3 (STAT3) inhibitor:
- to analyze its effects on malignant peripheral nerve sheath tumor (MPNST) survival and proliferation
- to study its effects on the thymic stromal lymphopoietin (TSLP) modulation of nometastatic gene 23-H1 (NME1 or nm23-H1) expression in human trophoblasts
- to study its effects on 17β-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced M2 polarization in human macrophages and endometrial stromal cells
Biochem/physiol Actions
5, 15-DPP is a selective STAT3 inhibitor and a selective STAT3-SH2 antagonist
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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