Key Documents

View All Documentation

D4788

2′-Deoxyadenosine 5′-triphosphate sodium salt solution

Name: 2&#8242;-Deoxyadenosine 5&#8242;-triphosphate sodium salt solution
Brand: SIGMA

≥99%, liquid

Synonym(s):

dATP

Select a Size

Change View

About This Item

UNSPSC Code:

41106305

eCl@ss:

32160414

PubChem Substance ID:

24893898

NACRES:

NA.52

EC Number:

217-662-3

Assay:

≥99%

Form:

liquid

Storage temp.:

−20°C

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Product Name

2′-Deoxyadenosine 5′-triphosphate sodium salt solution, 100 mM, pH 7

assay

≥99%

Quality Level

300

form

liquid

concentration

100 mM

color

colorless

pH

foreign activity

DNase, RNase, none detected

shipped in

dry ice

storage temp.

−20°C

SMILES string

[Na+].Nc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)([O-])=O)O3

InChI

1S/C10H16N5O12P3.Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);/q;+1/p-1/t5-,6+,7+;/m0./s1

InChI key

YJWCICGGRLOGEH-VWZUFWLJSA-M

Looking for similar products? Visit Product Comparison Guide

Related Categories

PCR & Amplification

PCR Reagents & Kits

Phosphates

General description

2′-Deoxyadenosine 5′-triphosphate (dATP) is made up of a nucleobase attached to deoxyribose and a 5′-hydroxyl on the sugar bound to a chain of three phosphate residues. dATP is used by cells for synthesis of DNA by DNA polymerases.

Application

2′-Deoxyadenosine 5′-triphosphate sodium salt solution has been used in the detection of apoptotic cells by the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) technique. It has also been used to induce oligomerization of apoptotic protease activating factor-1 (Apaf-1) to form a large heptameric complex referred to as the apoptosome or Apaf-1 procaspase-9 apoptosome complex and to study its functions as a proteolytic-based molecular timer.

2′-Deoxyadenosine 5′-triphosphate sodium salt solution is used in DNA sysnthesis reactions such as PCR, DNA sequencing and molecular cloning techniques.

Other Notes

T4 DNA Ligaes is supplied in a solution containing 20 mM Tris-HCl(ph 7.5), 50mM KCl, 1mM DTT, and 50% (v/v) glycerol

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Ultrasound-guided intramural inoculation of orthotopic bladder cancer xenografts: a novel high-precision approach

Jager W, et al.

Testing, 8(3), e59536-e59536 (2013)

The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.

Srinivas Malladi et al.

The EMBO journal, 28(13), 1916-1925 (2009-06-06)

During stress-induced apoptosis, the initiator caspase-9 is activated by the Apaf-1 apoptosome and must remain bound to retain significant catalytic activity. Nevertheless, in apoptotic cells the vast majority of processed caspase-9 is paradoxically observed outside the complex. We show herein

How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations.

Serdal Kirmizialtin et al.

Structure (London, England : 1993), 20(4), 618-627 (2012-04-10)

Nearly every enzyme undergoes a significant change in structure after binding it's substrate. Experimental and theoretical analyses of the role of changes in HIV reverse transcriptase structure in selecting a correct substrate are presented. Atomically detailed simulations using the Milestoning

Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway.

U C Halder et al.

Cell death & disease, 2, e197-e197 (2011-09-02)

During early infection, viruses activate cellular stress-response proteins such as heat-shock proteins (Hsps) to counteract apoptosis, but later on, they modulate these proteins to stimulate apoptosis for efficient viral dissemination. Hsp70 has been attributed to modulate viral entry, transcription, nuclear

Tangled up in knots: structures of inactivated forms of E. coli class Ia ribonucleotide reductase.

Christina M Zimanyi et al.

Structure (London, England : 1993), 20(8), 1374-1383 (2012-06-26)

Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli class Ia RNR by driving formation of RNR subunits

View All Related Papers

Global Trade Item Number

SKU	GTIN
D4788-.1MMO	04061833451014
D4788-25UMO	04061833585696

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service