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D4921

Destruxin A from Metarrhizium anisopliae

≥98% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C29H47N5O7
CAS Number:
6686-70-0
Molecular Weight:
577.71
NACRES:
NA.32
PubChem Substance ID:
329798802
UNSPSC Code:
12352200
MDL number:
MFCD01736100
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biological source

Metarrhizium anisopliae

Quality Level

200

assay

≥98% (HPLC)

form

powder

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@H]2CCCN2C(=O)[C@H](CC=C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C1=O

InChI

1S/C29H47N5O7/c1-9-12-21-27(38)34-16-11-13-20(34)26(37)31-23(18(5)10-2)28(39)33(8)24(17(3)4)29(40)32(7)19(6)25(36)30-15-14-22(35)41-21/h9,17-21,23-24H,1,10-16H2,2-8H3,(H,30,36)(H,31,37)/t18-,19-,20+,21-,23-,24-/m0/s1

InChI key

XIYSEKITPHTMJT-UTJJDKHZSA-N

Application

Destruxin A from Metarrhizium anisopliae has been used for immersion and inoculation bioassay in Rhipicephalus (Boophilus) microplus. It has been used as a transport inhibitor in Drosophila melanogaster.

Biochem/physiol Actions

Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response. Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase. It is virustatic against arboviruses.

Analysis Note

Balance is other destruxins

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

高风险级别生物产品--毒素类产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000213607
0000213607
0000223599
0000223599
0000161735

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Stefan Hutwimmer et al.
Mycologia, 102(1), 1-10 (2010-02-03)
Nutritional conditions causing droplet exudation by Metarhizium anisopliae var. anisopliae were studied. Exudation in droplets occurred only on media with more than one carbon source and was highly dependent on the ratio of a well metabolized sugar such as trehalose
Kopecky, J., et al.
Comparative Biochemistry and Physiology, 103C, 23-23 (1992)
Xiang Meng et al.
Toxicon : official journal of the International Society on Toxinology, 58(4), 327-335 (2011-07-02)
The cytotoxicity of a destruxin A (DA) treatment of Spodoptera litura SL-1 cells was investigated. An MTT assay showed that DA was highly toxic to SL-1 cells in a concentration- and time-dependent manner. The IC(50) values of DA, after 24 h
Patrícia Silva Gôlo et al.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 20(4), 338-341 (2011-12-15)
This study evaluated the effects of destruxin A on Rhipicephalus (Boophilus) microplus females, since this toxin is one of the likely causes of high mortality induced by the entomopathogenic fungus Metarhizium anisopliae in arthropods. Ticks were immersed or inoculated with
Esau Ruiz-Sanchez et al.
Toxicon : official journal of the International Society on Toxinology, 55(6), 1162-1170 (2010-01-12)
The production of peptide toxins by entomopathogenic fungi during the infection process plays critical roles in pathogenesis. To gain insight into the mechanism of action of these mycotoxins on insect internal organs, we have evaluated the effects of destruxin A
View All Related Papers

Global Trade Item Number

SKUGTIN
D4921-1MG04061833585887

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