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D5943

2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

Name: 2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

Flt-3 inhibitor

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₀N₂O₄S

CAS Number:

301305-73-7

Molecular Weight:

360.43

NACRES:

NA.77

PubChem Substance ID:

24724465

UNSPSC Code:

12352106

MDL number:

MFCD00617269

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

protect from light, under inert gas

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

protect from light, under inert gas

color

white to off-white

solubility

H₂O: <2 mg/mL, DMSO: ~8 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O

InChI

1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)

InChI key

FSPQCTGGIANIJZ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Flt-3 (fms-related tyrosine kinase 3) inhibitor

Features and Benefits

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

106K4623

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Articles

PDGFR

We offers many products related to PDGFR for your research needs.

Identification of 2-acylaminothiophene-3-carboxamides as potent inhibitors of FLT3.

Raymond J Patch et al.

Bioorganic & medicinal chemistry letters, 16(12), 3282-3286 (2006-04-04)

A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 microM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 microM). Structure-activity relationship

Global Trade Item Number

SKU	GTIN
D5943-5MG	04061832445366
D5943-25MG	04061832270326