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Merck
CN

D5943

2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

≥98% (HPLC), solid

Synonym(s):

Flt-3 inhibitor

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About This Item

Empirical Formula (Hill Notation):
C18H20N2O4S
CAS Number:
301305-73-7
Molecular Weight:
360.43
NACRES:
NA.77
PubChem Substance ID:
24724465
UNSPSC Code:
12352106
MDL number:
MFCD00617269

Key Documents

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InChI key

FSPQCTGGIANIJZ-UHFFFAOYSA-N

SMILES string

COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O

InChI

1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)

assay

≥98% (HPLC)

form

solid

storage condition

protect from light, under inert gas

color

white to off-white

solubility

H2O: <2 mg/mL, DMSO: ~8 mg/mL

storage temp.

−20°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Flt-3 (fms-related tyrosine kinase 3) inhibitor

Features and Benefits

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
106K4623

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Raymond J Patch et al.
Bioorganic & medicinal chemistry letters, 16(12), 3282-3286 (2006-04-04)
A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 microM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 microM). Structure-activity relationship

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