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Merck
CN

D6035

Disopyramide phosphate salt

Synonym(s):

α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide

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About This Item

Linear Formula:
C21H29N3O · H3PO4
CAS Number:
22059-60-5
Molecular Weight:
437.47
NACRES:
NA.77
PubChem Substance ID:
24277706
UNSPSC Code:
12352200
EC Number:
244-756-1
MDL number:
MFCD00069254

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InChI key

CGDDQFMPGMYYQP-UHFFFAOYSA-N

InChI

1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)

SMILES string

OP(O)(O)=O.CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C

form

solid

Quality Level

200

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Application

Disopyramide phosphate salt has been used as an internal standard for plasma sample analysis by mass spectrometry. It might be used as a test compound in a teratogenicity study.

Biochem/physiol Actions

Class IA antiarrhythmic; sodium channel blocker
Disopyramide is found to stabilize the cell membrane by altering the action potential. It might act as an antiarrhythmic agent.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000484047
0000484047
018F0560

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Akihito Yamashita et al.
The Journal of toxicological sciences, 39(3), 453-464 (2014-05-23)
The zebrafish has been considered as a suitable animal model for drug discovery, especially for evaluation of the teratogenicity, due to their small size, rapid development, transparency, and developmental similarities to mammalian development. These features of zebrafish make it possible
0
Drugs for Pregnant and Lactating Women, 252-338 (2009)
Anthony A Fossa et al.
The Journal of pharmacology and experimental therapeutics, 302(2), 828-833 (2002-07-20)
QT interval prolongation of the electrocardiogram has been associated with the occurrence of life-threatening fatal ventricular arrhythmias. To understand the relationship between preclinical cardiac conduction assessment to clinical outcome, comparisons of free (unbound)-plasma drug concentrations and their associated effects in
Dan Musat et al.
Progress in cardiovascular diseases, 54(6), 535-542 (2012-06-13)
Pharmacologic therapy is the first line approach to relieve symptoms in obstructive hypertrophic cardiomyopathy. There are no randomized trials to evaluate their effect on prognosis. Gradient reduction by surgical septal myectomy is associated with excellent prognosis, but not all patients
Enrique Ochoa-Aranda et al.
Journal of AOAC International, 94(2), 537-542 (2011-05-14)
A micellar liquid chromatography (MLC) method using a C18 column was developed to determine three antiarrhythmic drugs--disopyramide, lidocaine, and quinidine--that are most usually monitored in serum samples. After the application of an interpretative strategy for optimization of sodium dodecyl sulfate
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