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About This Item
Linear Formula:
C21H29N3O · H3PO4
CAS Number:
Molecular Weight:
437.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
244-756-1
MDL number:
InChI key
CGDDQFMPGMYYQP-UHFFFAOYSA-N
InChI
1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
SMILES string
OP(O)(O)=O.CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C
form
solid
Quality Level
Gene Information
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Related Categories
Application
Disopyramide phosphate salt has been used as an internal standard for plasma sample analysis by mass spectrometry. It might be used as a test compound in a teratogenicity study.
Biochem/physiol Actions
Class IA antiarrhythmic; sodium channel blocker
Disopyramide is found to stabilize the cell membrane by altering the action potential. It might act as an antiarrhythmic agent.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Akihito Yamashita et al.
The Journal of toxicological sciences, 39(3), 453-464 (2014-05-23)
The zebrafish has been considered as a suitable animal model for drug discovery, especially for evaluation of the teratogenicity, due to their small size, rapid development, transparency, and developmental similarities to mammalian development. These features of zebrafish make it possible
0
Drugs for Pregnant and Lactating Women, 252-338 (2009)
Anthony A Fossa et al.
The Journal of pharmacology and experimental therapeutics, 302(2), 828-833 (2002-07-20)
QT interval prolongation of the electrocardiogram has been associated with the occurrence of life-threatening fatal ventricular arrhythmias. To understand the relationship between preclinical cardiac conduction assessment to clinical outcome, comparisons of free (unbound)-plasma drug concentrations and their associated effects in
Aziza El Harchi et al.
Journal of molecular and cellular cardiology, 52(1), 185-195 (2011-10-13)
The Class Ia antiarrhythmic drug disopyramide (DISO) causes QT interval prolongation that is potentially dangerous in acquired Long QT Syndrome but beneficial in short QT syndrome, through inhibition of the hERG-encoded channels responsible for rapid delayed rectifier K(+) current (I(Kr)).
Shunichiro Sumi et al.
Pacing and clinical electrophysiology : PACE, 33(6), e53-e56 (2010-01-12)
The patient was a 57-year-old man with Brugada syndrome, who had been implanted with a implantable cardioverter defibrillator (ICD). The frequency of ventricular fibrillation (VF) started to increase about 4 years after ICD implantation, occurring, at worst, six times in
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