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Merck
CN

D6277

N-Decanoyl-N-methylglucamine

≥98% (GC)

Synonym(s):

N-(D-Glucityl)-N-methyldecanamide, N-Decanoyl-N-methyl-D-glucamine, MEGA-10

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About This Item

Empirical Formula (Hill Notation):
C17H35NO6
CAS Number:
85261-20-7
Molecular Weight:
349.46
Beilstein:
6974359
MDL number:
MFCD00036801
UNSPSC Code:
12161900
PubChem Substance ID:
24894017
NACRES:
NA.25

Key Documents

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description

non-ionic

Assay

≥98% (GC)

form

powder

mol wt

349.46 g/mol

technique(s)

ligand binding assay: suitable
protein purification: suitable

CMC

6-7 mM (20-25°C)

storage temp.

2-8°C

SMILES string

OCC(O)C(O)C(O)C(O)CN(C)C(CCCCCCCCC)=O

InChI

1S/C17H35NO6/c1-3-4-5-6-7-8-9-10-15(22)18(2)11-13(20)16(23)17(24)14(21)12-19/h13-14,16-17,19-21,23-24H,3-12H2,1-2H3

InChI key

UMWKZHPREXJQGR-UHFFFAOYSA-N

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General description

N-Decanoyl-N-methylglucamine is a nonionic detergent used in lysis buffers.

Application

N-Decanoyl-N-methylglucamine has been used in a study to assess the effect of surfactants on wetting behavior of super-hydrophobic surfaces. It has also been used in a study to investigate the clinical impact of Human metapneumovirus (hMPV) vaccines on Syrian golden hamsters.
Non-ionic, dialyzable detergent used for the solubilization of membrane proteins

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000491487
0000491483
0000491487
0000491483
0000429949

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Sander Herfst et al.
The Journal of general virology, 88(Pt 10), 2702-2709 (2007-09-18)
Human metapneumovirus (hMPV), a newly discovered paramyxovirus, is associated with acute respiratory-tract illness, primarily in young children, individuals with underlying disease and the elderly. Two genetic lineages of hMPV circulate around the world, and viruses from these two lineages demonstrate
Khemraj Budachetri et al.
mBio, 11(4) (2020-07-30)
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, an emerging disease transmitted by the Lone Star tick, Amblyomma americanum. E. chaffeensis outer membrane protein entry triggering protein of Ehrlichia (EtpE) is necessary for bacterial entry into
R Mohammadi et al.
Langmuir : the ACS journal of surfaces and colloids, 20(22), 9657-9662 (2004-10-20)
The effect of surfactants on wetting behavior of super-hydrophobic surfaces was investigated. Super-hydrophobic surfaces were prepared of alkylketene dimer (AKD) by casting the AKD melt in a specially designed mold. Time-dependent studies were carried out, using the axisymmetric drop shape
C Carnero Ruiz et al.
Biomacromolecules, 8(8), 2497-2503 (2007-07-17)
The protein-surfactant system constituted by bovine serum albumin (BSA) and N-decanoyl-N-methylglucamide (MEGA-10) has been studied by using surface tension, steady-state fluorescence, and dynamic light scattering measurements. It was found that the presence of protein delays the surfactant aggregation, which was
Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins
Chuang, J., et al.
Analytical Biochemistry, 418, 3-3 (2011)
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