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About This Item
Linear Formula:
(CH3)2NCH2COOH · HCl
CAS Number:
Molecular Weight:
139.58
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
219-648-2
MDL number:
Beilstein/REAXYS Number:
3910578
Product Name
N,N-Dimethylglycine hydrochloride,
Quality Level
InChI key
FKASAVXZZLJTNX-UHFFFAOYSA-N
InChI
1S/C4H9NO2.ClH/c1-5(2)3-4(6)7;/h3H2,1-2H3,(H,6,7);1H
SMILES string
Cl.CN(C)CC(O)=O
assay
≥98%
form
powder
technique(s)
ligand binding assay: suitable
color
white
mp
189-194 °C (lit.)
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Biochem/physiol Actions
N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Shuichi Setoguchi et al.
Molecules (Basel, Switzerland), 25(3) (2020-02-06)
The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility. We prepared three novel N,N-dimethylglycine
Characterization of osmolyte βine synthesizing sarcosine dimethylglycineN-methyltransferase from Methanohalophilus portucalensis.
Chen SY, Lai MC, Lai SJ, Lee YC.
Applied Microbiology, 191, 735-743 (2009)
A J Hoorn
Mutation research, 222(4), 343-350 (1989-04-01)
Dimethylglycine (DMG) and the chemically related amino acids glycine, sarcosine (monomethylglycine) and betaine (trimethylglycine) were tested in Salmonella typhimurium strain TA100 after treatment with sodium nitrite under acidic conditions using a modified Ames Salmonella/microsome assay as reported by Colman et
Jing-Fang Zhu et al.
The journal of physical chemistry. B, 116(1), 113-119 (2011-12-14)
The experimental and theoretical enthalpies of formation of several structural-similar glycine-based sulfate/bisulfate amino acid ionic liquids including glycine sulfate (Gly(2)SO(4), 1), glycine bisulfate (GlyHSO(4), 2), N,N-dimethylglycine sulfate ([DMGly](2)SO(4), 3), N,N-dimethylglycine bisulfate ([DMGly]HSO(4), 4), N,N-dimethylglycine methyl ester sulfate ([DMGlyC(1)](2)SO(4), 5), N,N-dimethylglycine
Baljit K Ubhi et al.
The European respiratory journal, 40(2), 345-355 (2011-12-21)
There is a paucity of biomarkers for chronic obstructive pulmonary disease (COPD). Metabolomics were applied to a defined COPD patient cohort from the ECLIPSE study (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points). Results were correlated with accepted biomarkers
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