D6413
Diloxanide furoate
Synonym(s):
2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide 2-furoic acid ester
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About This Item
Empirical Formula (Hill Notation):
C14H11Cl2NO4
CAS Number:
Molecular Weight:
328.15
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
223-108-1
MDL number:
antibiotic activity spectrum
parasites
SMILES string
CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1
InChI
1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3
InChI key
BDYYDXJSHYEDGB-UHFFFAOYSA-N
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Tsukasa Fujishima et al.
Chemotherapy, 56(4), 348-352 (2010-08-20)
A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy
Treatment of asymptomatic intestinal Entamoeba histolytica infection.
Joerg Blessmann et al.
The New England journal of medicine, 347(17), 1384-1384 (2002-10-25)
Asteria Luzardo Álvarez et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(1), 215-227 (2012-06-20)
We present a new strategy to suppress the attachment of Cryptosporidium parvum to the enterocytes cell surface by bioadhesive microspheres. An optimized microsphere system based on chitosan/poly(vinyl alcohol) was prepared by experimental design for the delivery of Diloxanide Furoate-cyclodextrin complex.
Julieta B Monteiro et al.
International journal of pharmaceutics, 267(1-2), 93-100 (2003-11-07)
In this study, we investigated the susceptibility to enzymatic and alkaline hydrolysis of diloxanide furoate (DF) and its cyclodextrin inclusion complexes, in aqueous solution. The cyclodextrins (CDs) utilized were beta-cyclodextrin (beta-CD), (2,6-di-O-methyl)-beta-cyclodextrin (DM-beta-CD) and (2,3,6-tri-O-methyl)-beta-cyclodextrin (TM-beta-CD). All cyclodextrins studied provided
H Qureshi et al.
The Journal of international medical research, 25(3), 167-170 (1997-05-01)
A combined formulation of diloxanide furoate and metronidazole was used to treat amoebiasis and giardiasis (cysts and vegetative forms) in 54 patients. Of these 34 patients had amoebiasis, 19 had giardiasis and one had mixed infection. Each patient took one
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